Mechanisms of life-course socioeconomic inequalities in adult systemic inflammation: Findings from two cohort studies

Publication date: Available online 19 November 2019Source: Social Science & MedicineAuthor(s): Cristian Carmeli, Johan Steen, Dusan Petrovic, Benoît Lepage, Cyrille Delpierre, Michelle Kelly-Irving, Murielle Bochud, Mika Kivimäki, Paolo Vineis, Silvia StringhiniAbstractDisadvantaged socioeconomic conditions in childhood heighten systemic inflammatory levels in adulthood; however, life-course mechanisms underlying this association are largely unknown. In the present observational study, we investigated the roles of adulthood socioeconomic and lifestyle factors in mediating this association.Participants were from two prospective Swiss population-based cohorts (N = 5,152, mean age 60 years). We estimated the total effect of paternal occupational position on adult heightened systemic inflammatory levels (C-reactive protein>3 mg/L), and the indirect effects via adulthood socioeconomic positions (SEPs: education and occupational position), financial hardship, and lifestyle factors (body mass index, smoking status, physical inactivity, and alcohol consumption). We estimated odds ratio (OR) and proportion mediated using counterfactual-based mediation models.Individuals whose father had a low occupational position had an OR of 1.51 [95% confidence interval (CI): 1.25, 1.84] for heightened inflammation compared to their more advantaged counterparts. This was jointly mediated (33 [95% CI: 14, 69]%) by adulthood SEPs, whereby the pathway through education followed by occupational...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research