Cell proliferation detected using 18 FFLT PET/CT as an early marker of abdominal aortic aneurysm
AbstractBackgroundAbdominal aortic aneurysm (AAA) is a focal aortic dilatation progressing towards rupture. Non-invasive AAA-associated cell proliferation biomarkers are not yet established. We investigated the feasibility of the cell proliferation radiotracer, fluorine-18-fluorothymidine ([18F]FLT) with positron emission tomography/computed tomography (PET/CT) in a progressive pre-clinical AAA model (angiotensin II, AngII infusion).Methods and ResultsFourteen-week-old apolipoprotein E-knockout (ApoE−/−) mice received saline or AngII via osmotic mini-pumps for 14 (n = 7 and 5, respectively) or 28 (n = 3 and 4, respectively) days and underwent 90-minute dynamic [18F]FLT PET/CT. Organs were harvested from independent cohorts for gamma counting, ultrasound scanning, and western blotting. [18F]FLT uptake was significantly greater in 14- (n = 5) and 28-day (n = 3) AAA than in saline control aortae (n = 5) (P
Introduction: Yearly imaging surveillance is recommended to all patients following endovascular aortic repair (EVAR) to detect complications requiring re-intervention. EVAR is currently the predominant technique for elective infrarenal abdominal aortic aneurysm (AAA) repair in the Netherlands. Consequently, a cumulative amount of hospital visits for imaging surveillance will arise. This causes a burden on both patients and the healthcare system. We therefore aimed to study the re-intervention free survival and survival stratified for patients with and without yearly imaging surveillance.
A 75-year-old morbidly obese man presented with increasing diameter of a known abdominal aortic aneurysm (AAA) and right common iliac artery aneurysm. He was diagnosed with these aneurysms at the age of 69 years while undergoing computed tomography for evaluation of pancreatic cancer. At the time of diagnosis, the AAA diameter was 3.9 cm. His past medical history was significant for hypertension and hyperlipidemia. He was observed with serial aortoiliac duplex ultrasound scans. By November 2018 (6 years after the original diagnosis), the AAA diameter increased to 6.3 cm and the right common iliac arte...
Conclusions: Using an established mouse model of AAA, we successfully demonstrated in vivo targeting of EL-GNPs to damaged aortic elastin and correlated micro-CT-based signal intensities with burst pressures. Thus, we show that this novel targeting technique can be used as a diagnostic tool to predict the degree of elastin damage and therefore rupture potential in AAAs better than the extent of dilation.
We present a case of successfully treated abdominal aortic aneurysm in a 24-year old patient with Marfan ’s syndrome. Following initial physical and ultrasound examination, the multislice computed tomography scan revealed infrarenal aortic aneurysm of 6 cm in diameter, 10 cm long, along with slightly dilated iliac arteries. However, dimensions of aortic root, aortic arch and descending suprarenal aor ta were within normal limits. Further on, since the patient presented with signs of impending rupture, an urgent surgical intervention was performed.
We present a case of successfully treated abdominal aortic aneurysm in a 24-year-old patient with Marfan syndrome. After initial physical and ultrasound examination, the multislice computed tomography (MSCT) scan revealed infrarenal aortic aneurysm of 6 cm in diameter, 10 cm long, along with slightly dilated iliac arteries. However, dimensions of aortic root, aortic arch, and descending suprarenal aorta were within normal limits. Further on, because the patient presented with signs of impending rupture, an urgent surgical intervention was perfor med.
CONCLUSIONS: The mid-term experience with Ovation demonstrates safe, durable treatment of iAAAs, including those with unfavourable anatomy, frequently off IFU for other commonly used devices. PMID: 29292208 [PubMed - as supplied by publisher]
This review demonstrates that both ultrasound modalities (with or without contrast) showed high specificity. For ruling in endoleaks, contrast-enhanced color duplex ultrasound (CE-CDUS) appears superior to CDUS. In an endoleak surveillance program, CE-CDUS can be introduced as a routine diagnostic modality followed by CT scan only when the ultrasound is positive to establish the type of endoleak and the subsequent therapeutic management.
BY KATE BANKS, MDThe Himalayan Health Exchange (HHE) is an organization that assembles volunteers and health care providers from all over the world to deliver care in underserved areas in northern India. I had the amazing opportunity in my second year of residency to spend a month delivering medical care with HHE in the beautiful inner Himalayan mountains. The month was full of exploring, trekking, camping, learning, doctoring, and personal and professional growth.The clinics were scattered throughout different areas in the state of Himachal Pradesh. Our convoy of interpreters, cooks, volunteers, and health care profess...
DiscussionCurrently, there is no known medical therapy to limit AAA progression. The IMAGEN trial will be the first randomised trial, to our knowledge, to assess the value of myo-inositol in limiting AAA growth.Trial registrationAustralian New Zealand Clinical Trials Registry,ACTRN12615001209583. Registered on 6 November 2015.
CONCLUSIONS: These data support efforts to improve compliance with imaging surveillance after EVAR. PMID: 28765015 [PubMed - as supplied by publisher]