Relationships between plasma lactate, plasma alanine, genetic variations in lactate transporters and type 2 diabetes in the Japanese population.

Relationships between plasma lactate, plasma alanine, genetic variations in lactate transporters and type 2 diabetes in the Japanese population. Drug Metab Pharmacokinet. 2019 Oct 17;: Authors: Higuchi I, Kimura Y, Kobayashi M, Narumi K, Furugen A, Miyoshi H, Nakamura A, Yamada T, Atsumi T, Iseki K Abstract The present study aimed to characterize the relationships between plasma lactate, plasma alanine, monocarboxylate transporter (MCT) polymorphisms, and indices of diabetes in patients with type 2 diabetes (T2D) in Japan. Eighty-three patients with T2D were prospectively enrolled. The gluconeogenesis and glycogenolysis are enhanced and uptake of glucose is decreased in the T2D liver. Since the liver plays an important role in maintaining glucose metabolism, we examined the relationships between liver enzymes and indices of diabetes. Some studies have reported that MCT1 (SLC16A1) polymorphism causes metabolic diseases. In addition, a high frequency of MCT1 polymorphism was reported in a healthy Japanese population. However, little is known about the relationships between T2D and MCT polymorphisms. Plasma l-lactate concentration positively correlated with indices of diabetes (fasting plasma glucose [FPG] and hemoglobin A1c [HbA1c]) and with the liver enzymes alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (γ-GTP). MCT1 polymorphisms were associated with all of these markers. We identified no significant correlations between d-lactate...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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Source: Molecular Metabolism - Category: Endocrinology Source Type: research
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Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
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Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Type 2 Diabetes;   Gestational Diabetes Intervention:   Other: Observational Sponsors:   Universiti Putra Malaysia;   Ministry of Health, Malaysia;   Universiti Teknologi Mara Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Society for Endocrinology - Category: Endocrinology Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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