Direct bilirubin level is an independent risk factor for atrial fibrillation in thyrotoxic patients receiving radioactive iodine therapy

This study aimed to indicate the risk factors of atrial fibrillation (AF) in thyrotoxic patients receiving radioactive iodine (RAI) therapy after antithyroid drug and other medication. Methods This study was a retrospective cohort study. Thyrotoxic patients were divided into two groups, with or without AF. Clinical features were retrospectively analyzed. Univariate and multivariate analyses of data from thyrotoxic patients were performed to evaluate the probability of AF. Results The following clinical factors were found to be correlated with AF: age, gender, duration of hyperthyroidism, coronary artery disease, hypertension, and levels of platelets, creatinine, uric acid (UA), and certain liver enzymes. According to the multiple logistic regression model, age and levels of UA, direct bilirubin (DBIL), and gamma-glutamyl transpeptidase (GGT) were important risk factors for predicting AF. ROC analysis showed that DBIL levels were predictive of AF, with a specificity of 0.813, a sensitivity of 0.767, and an area under the curve of 0.8515 (P
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research

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A simple clinical score, C2HEST (C2: CAD / COPD (1 point each); H: Hypertension; E: Elderly (Age ≥75, doubled); S: Systolic HF (doubled); T: Thyroid disease (hyperthyroidism)) has been proposed to predict incident AF, with good discrimination and internal calibration. To define high risk patients at particular age strata for incident AF in a nationwide population cohort, who could potentially be targeted for AF screening, we used a nationwide cohort study of all Danish citizen aged ≥65 years to evaluate the performance of the C2HEST score.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
CONCLUSIONS: The prevalence of CT in patients with overt hyperthyroidism was relatively low. Cardiac complications were AF and CHF with a clear predominance of AF. Advanced age was the only independent risk factor of CT. Cardiac complications may be seen even if hyperthyroidism is not biologically severe. PMID: 31235068 [PubMed - as supplied by publisher]
Source: Annales d'Endocrinologie - Category: Endocrinology Authors: Tags: Ann Endocrinol (Paris) Source Type: research
Authors: Lozano-Velasco E, Garcia-Padilla C, Aránega AE, Franco D Abstract Atrial fibrillation (AF) is the most frequent arrhythmogenic disease in humans, ranging from 2% in the general population and raising up to 10-12% in 80+ years. Genetic analyses of AF familiar cases have identified a series of point mutations in distinct ion channels, supporting a causative link. However, these genetic defects only explain a minority of AF patients. Genome-wide association studies identified single nucleotide polymorphisms (SNPs), close to PITX2 on 4q25 chromosome, that are highly associated to AF. Subsequent GWAS stu...
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
ConclusionEarly repolarization was associated with lone atrial fibrillation. Early repolarization may indicate increased susceptibility to atrial fibrillation.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
Abstract BACKGROUND: The incidence of atrial fibrillation (AF) is increasing, conferring a major healthcare issue in Asia. No risk score for predicting incident AF has been specifically developed in Asian subjects. Our aim was to investigate risk factors for incident AF in Asian subjects and to combine them into a simple clinical risk score. METHODS: Risk factors for incident AF were analyzed in 471,446 subjects from the Chinese Yunnan Insurance Database (internal derivation cohort), and then combined into a simple clinical risk score. External application of the new score was performed in 451,199 subjects fr...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Conclusions: Older age and levels of UA, DBIL, and GGT influenced the occurrence of AF in thyrotoxic patients receiving RAI. DBIL level was an important factor in predicting AF in patients with hyperthyroidism. Thus, thyrotoxic patients who have the above-mentioned risk factors should undergo routine pulse palpation and active antithyroid drug therapy. Keywords: Atrial Fibrillation, Hyperthyroidism, Clinical Feature, Radioactive Iodine Therapy, Direct Bilirubin
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
We report a case of a male patient with stroke caused by atrial fibrillation (AF) due to thyrotoxicosis. At hospital admission, he presented hypertension and AF. Magnetic resonance imaging confirmed a right-side ischemic area. The thyrotoxicosis was confirmed by thyroid function and thyroid scintigraphy that showed goiter with diffuse hypercaptation. The patient was treated with tapazole and total thyroidectomy, and pathological findings suggested Graves ’ disease. Hyperthyroidism is associated with increased supraventricular ectopic activity in patients with a normal heart, and may be an important causal link betwee...
Source: Case Reports in Neurology - Category: Neurology Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to determine the role of pulmonary vein (PV) triggers in different types of atrial fibrillation (AF) as well as to determine based on prospective randomized data which other approaches may increase the success rate of radiofrequency ablation of persistent AF.Recent FindingsSpecial attention must be paid to detect, diagnose, and optimize management of reversible or treatable causes of persistent AF such as obesity, obstructive sleep apnea, hypertension, hypo- or hyperthyroidism, inflammatory and infectious diseases, and stress. Though the role of PVs is more pronounced ...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
Opinion statementSpecial attention must be paid to detect, diagnose, and optimize management of reversible or treatable causes of long-standing persistent atrial fibrillation (LSPAF) such as obesity, obstructive sleep apnea (OSA), hypertension, hypo or hyperthyroidism, inflammatory and infectious diseases, and stress. Though, we strongly believe that the role of the pulmonary veins (PVs) is more pronounced in paroxysmal atrial fibrillation (AF) than in persistent AF, performing an adequate pulmonary vein isolation is still key in LSPAF. Patients with LSPAF will frequently require a more aggressive mapping and ablative appr...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
In this study the majority of the patients (78), i.e., 22.03% were in the age group of 61–70 years. Majority of the patients were female (58.19%). Males comprised of 41.81%. The common symptoms of atrial fibrillation in the patients were palpitation 85.31% and breathlessness 82.77%. Next common symptoms were fatigue 73.16%, PND 70.06% and swelling of dependant parts 68.93% respectively. Giddiness 57.91% and orthopnea 53.67% were the next common presenting symptoms. Chest pain was the presenting complaint in 22.32% cases and limb weakness or stroke in 7.34% cases. Involuntary movements 3.95% and sleep apnea 1.97% were...
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research
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