The association of AGO1 (rs595961G > A, rs636832A > G) and AGO2 (rs11996715C > A, rs2292779C > , rs4961280C > A) polymorphisms and risk of recurrent implantation failure.

The association of AGO1 (rs595961G>A, rs636832A>G) and AGO2 (rs11996715C>A, rs2292779C>, rs4961280C>A) polymorphisms and risk of recurrent implantation failure. Biosci Rep. 2019 Nov 14;: Authors: Ryu CS, Kim YR, Kim JO, An HJ, Cho SH, Ahn EH, Kim JH, Lee WS, Kim NK Abstract Recurrent implantation failure (RIF) is a common reproductive clinical condition treated by fertility specialists at in vitro fertilization (IVF) clinics. Several factors affect embryo implantation including the age of the female, the quality of embryos and the sperm, genetics, immunologic factors. Here, we investigated the association of Argonaute 1 (AGO1) and Argonaute 2 (AGO2) polymorphisms and RIF. We collected blood samples from 119 patients with RIF and 235 controls. Genetic polymorphisms were detected by polymerase chain reaction (PCR) - restriction fragment length polymorphism analysis and real-time PCR. We found that the AGO2 rs4961280C>A polymorphism (adjusted odds ratio [AOR] = 1.853; P=0.036) was significantly associated with RIF. Furthermore, in RIF patients with three or more consecutive implantation failure, the AGO2 rs4961280C>A CA genotype (AOR=1.956; P=0.027) and dominant model (AOR=2.034; P=0.018) were both significantly associated with prevalence of RIF. An analysis of variance revealed that patients with the AGO2 rs2292779C>G genotypes (CC: 6.52±2.55; CG: 7.46±3.02; GG: 8.42±2.74; P=0.044) and the dominant model (CC:...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research