A Study in Pregnant Women With Chronic Inflammatory Diseases Treated With Cimzia (Certolizumab Pegol)

Conditions:   Rheumatoid Arthritis;   Psoriatic Arthritis;   Crohn's Disease;   Axial Spondyloarthritis;   Plaque Psoriasis Intervention:   Drug: Pharmacokinetics of certolizumab pegol Sponsor:   UCB Biopharma S.P.R.L. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conditions:   Rheumatoid Arthritis;   Psoriatic Arthritis;   Crohn's Disease;   Axial Spondyloarthritis;   Plaque Psoriasis Intervention:   Drug: Pharmacokinetics of certolizumab pegol Sponsor:   UCB Biopharma S.P.R.L. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionThere was a preference for etanercept among pregnancies with AS/JIA/PsA/PsO/RA, despite the availability of other TNFis. Decline in TNFi use after the first trimester may be related to the desire to reduce TNFis transplacental transfer and to minimize infection risk to the fetus or baby associated with live vaccine immunizations after birth.
Source: Pharmacoepidemiology and Drug Safety - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL REPORT Source Type: research
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