Effect of maternal omega-3 fatty acids and vitamin E supplementation on placental apoptotic markers in rat model of early and late onset preeclampsia

Publication date: Available online 12 November 2019Source: Life SciencesAuthor(s): Vaishali Kasture, Anvita Kale, Karuna Randhir, Deepali Sundrani, Sadhana JoshiAbstractAimDisturbed placentation results in pregnancy complications like preeclampsia. Placental development is influenced by apoptosis during trophoblast differentiation and proliferation. Increased oxidative stress upregulates placental apoptosis. We have earlier reported increased oxidative stress, lower omega-3 fatty acids and vitamin E levels in women with preeclampsia. Current study examines effect of maternal omega-3 fatty acids and vitamin E supplementation on apoptotic markers across gestation in a rat model of preeclampsia.Main MethodsPregnant Wistar rats were randomly assigned to control; early onset preeclampsia (EOP); late onset preeclampsia (LOP); early onset preeclampsia + omega-3 fatty acid +vitamin E supplementation (EOP + O + E) and late onset preeclampsia + omega-3 fatty acid +vitamin E supplementation (LOP + O + E) groups. Animals (Control, EOP, EOP+O+E) were sacrificed at d14 and d20 of gestation while animals (LOP, LOP+O+E) were sacrificed at d20 to collect blood and placentae. Protein and mRNA levels of apoptotic markers were analysed by ELISA and RT-PCR respectively.Key FindingsProtein levels of proapoptotic markers like Bcl-2 associated X-protein (BAX) (p
Source: Life Sciences - Category: Biology Source Type: research

Related Links:

Background: Fertility preservation must be discussed with reproductive age women before cancer treatment. Heart transplantation raises complex issues in pregnancy. Pregnancy in a heart transplant woman after p...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Case report Source Type: research
ConclusionsAlthough further prospective research on the efficacy of chemotherapy during pregnancy is necessary, survival of patients diagnosed with early stage HL during pregnancy appears not to be statistically different from matched non-pregnant controls, Awareness of complications as preterm delivery and low birth weight is important in this population.Clinical trial identificationNTC00330447.Legal entity responsible for the studyThe authors.FundingEuropean Union ’s Horizon 2020 Research and Innovation Program under grant agreement No 647047 Research Foundation-Flanders (FWO., grant no G070514N) and ESGO (European...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 26 September 2019Source: The Lancet HaematologyAuthor(s): Giovanni Codacci-Pisanelli, Giuseppe Cimino
Source: The Lancet Haematology - Category: Hematology Source Type: research
Publication date: Available online 26 September 2019Source: The Lancet HaematologyAuthor(s): Charlotte Maggen, Daan Dierickx, Pieternella Lugtenburg, Annouschka Laenen, Elyce Cardonick, Roman Smakov, Mar Bellido, Alvaro Cabrera-Garcia, Mina Mhallem Gziri, Michael J Halaska, Petronella B Ottevanger, Kristel Van Calsteren, Andie O'Laughlin, Evgeniya Polushkina, Laura Van Dam, Irit Avivi, Peter Vandenberghe, F J Sherida H Woei-A-Jin, Frédéric Amant, International Network on Cancer, Infertility and PregnancySummaryBackgroundOutcomes for mother and child following a diagnosis of Hodgkin lymphoma during pregnancy a...
Source: The Lancet Haematology - Category: Hematology Source Type: research
ConclusionActual body weight and bone marrow involvement may be utilized as potential predictive indicators of R-IRRs. Further study is needed to validate these indicators and determine appropriate utilization in practice.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Conclusions: A close collaboration between Cancer and Fertility Center in a tertiary care hospital is essential to provide a good health service in oncological patients. Offering fertility preservation is no longer considered optional and must be included in every therapeutic program for women who receive an oncological diagnosis in their reproductive age. Oocyte cryopreservation is a good option for fertility preservation for women facing cancer treatment and our results, despite on a small sample, are encouraging. We also confirm a low utilization rate as only 4.5% of patients returned to use their gametes.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusion: This study indicates that BNIP3 is particularly important for decidualization and may contribute to both the occurrence and development of preeclampsia via mTOR/p70s6k/BCL-2 signaling pathways.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research
ConclusionActual body weight and bone marrow involvement may be utilized as potential predictive indicators of R-IRR. Further research is needed to validate these indicators and determine appropriate utilization in practice.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Authors: Hashimoto Y, Omura H, Tokuyasu Y, Nakamoto S, Tanaka T Abstract We experienced a pregnant woman with superior vena cava syndrome at 15 weeks of pregnancy who was diagnosed with primary mediastinal large B-cell lymphoma and given chemotherapy. In this case, the clinical courses of both the mother and infant were favorable without any serious complications because of close multidisciplinary cooperation. Based on a retrospective review of this case, the administration of CHOP-like regimens during the second and third trimesters appears relatively safe. Because pregnancy and continuation of pregnancy are rare ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Comes M, Batlle M, Ribera JM PMID: 31337491 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
More News: Biology | Kale | Lymphoma | Omega 3 | Pregnancy | Study | Vitamin E | Vitamins | Women