Corrigendum to “Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification” NeuroImage: Clinical, 24, 2019 / 101966

Publication date: Available online 13 November 2019Source: NeuroImage: ClinicalAuthor(s): Liron Rabany, Sophy Brocke, Vince D. Calhoun, Brian Pittman, Silvia Corbera, Bruce E. Wexler, Morris D. Bell, Kevin Pelphrey, Godfrey D. Pearlson, Michal Assaf
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd...
Source: Cell - Category: Cytology Source Type: research
Abstract Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general "p" factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N = 8161) and age 13 (N = 7017). PRS were generated from large publis...
Source: Behavior Genetics - Category: Genetics & Stem Cells Authors: Tags: Behav Genet Source Type: research
CONCLUSION: The PRS for schizophrenia was not associated with CUD in controls or patients with other psychiatric disorders than schizophrenia. This speaks against the hypothesis that shared genetic vulnerability would explain the association between cannabis and schizophrenia. PMID: 31813396 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
AbstractMajor psychiatric traits are genetically inter-correlated with one another, but it not well known which genes play pleiotropic effects across different traits. We curated and compared genes identified from large-scale genome-wide association studies for seven psychiatric traits, including depression, bipolar disorder, schizophrenia, autism spectrum disorder, attention-deficit/hyperactivity disorder, anxiety and neuroticism. We then explored biological functions of the top pleiotropic genes. A total of 243 cross-trait genes were identified for the seven traits. Except for autism spectrum disorder, there was signific...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Abstract Neuronal Calcium Sensor-1 or Frequenin is a calcium sensor widely expressed in the nervous system, with roles in neurotransmission, neurite outgrowth, synaptic plasticity, learning, and motivated behaviours. Neuronal Calcium Sensor-1 has been implicated in neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and bipolar disorder. However, the role of Neuronal Calcium Sensor-1 in behavioural phenotypes and brain changes relevant to autism spectrum disorder have not been evaluated. We show that Neuronal calcium sensor-1 deletion in the mouse leads to a mild deficit in social approac...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Publication date: Available online 5 December 2019Source: NeuronAuthor(s): Sehyoun Yoon, Euan Parnell, Maria Kasherman, Marc P. Forrest, Kristoffer Myczek, Susitha Premarathne, Michelle C. Sanchez Vega, Michael Piper, Thomas H.J. Burne, Lachlan A. Jolly, Stephen A. Wood, Peter PenzesSummaryVariants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known. Here, we show that ankyrin-G interacts with Usp9X, a neurodevelopmental-disorder-assoc...
Source: Neuron - Category: Neuroscience Source Type: research
by Tyler Buddell, Vladislav Friedman, Cody J. Drozd, Christopher C. Quinn Common and rare variants of theCACNA1C voltage-gated calcium channel gene have been associated with autism and other neurodevelopmental disorders including schizophrenia, bipolar disorder and ADHD. However, little is known about howCACNA1C variants affect cellular processes to alter neurodevelopment. The Timothy syndrome mutation is a rarede novo gain-of-function variant inCACNA1C that causes autism with high penetrance, providing a powerful avenue into investigating the role ofCACNA1C variants in neurodevelopmental disorders. Here, we useegl-19, th...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
We present evidence that the SAGA complex is necessary for homeostatic plasticity, demonstrating involvement of four new genes in homeostatic plasticity. This is also evidence that glia participate in presynaptic homeostatic plasticity, invoking previously unexplored intercellular, homeostatic signaling at a tripartite synapse. We show, mechanistically, SAGA signaling regulates the composition of and signaling from the extracellular matrix during homeostatic plasticity.
Source: Neuron - Category: Neuroscience Source Type: research
Abstract Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex can also influence the complexity and diversity of microbes that we harbour in our gut; and reciprocally that our gut microbes can directly and indirectly influence sex steroid hormones and central gene activation. There is a growing emphasis on the role of gastrointestinal microbiota in the ...
Source: Frontiers in Neuroendocrinology - Category: Endocrinology Authors: Tags: Front Neuroendocrinol Source Type: research
My dog Jack, thinking, has a proportionally larger hippocampus than you do. If I had a pet bunny, its hippocampus would be (proportionally) larger, still!! You’ve probably heard a lot about the crucial role that the hippocampus plays in recording our “episodic” (historic, serial, ‘long-term’) memories. Does this mean that we should revise that age old saying to “Molly has a memory like a… rabbit!” Or what?! Or put another way, what can a rabbit or dog DO, that is decisively superior to YOU? It turns out that dogs and especially rabbits have an exquisite ability to reconstruc...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - Category: Neuroscience Authors: Tags: Aging and the Brain Autism Origins, Treatments Brain Fitness Brain Trauma, Injury Childhood Learning Cognitive Impairment in Children Cognitive impairments Language Development Reading and Dyslexia Schizophrenia, Bipolar Disorder, et ali Source Type: blogs
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