Synthesis and evaluation of cyclic sulfite diesters as sulfur dioxide (SO2) donors.

We report 1,2-cyclic sulfite diesters as a new class of reliable SO2 donors that dissociate in buffer through a nucleophilic displacement to produce SO2 with tuneable release profiles. We provide data in support of the suitability of these SO2 donors to enhance intracellular levels of SO2 at an efficiency superior to sodium bisulfite, the most commonly used SO2 donor for cellular studies.
PMID: 31709695 [PubMed - as supplied by publisher]

Source: Chembiochem - November 9, 2019 Category: Biochemistry Authors: Malwal S, Pardeshi KA, Chakrapani H Tags: Chembiochem Source Type: research