Cerebral Aspergillosis Lesion Study (CEREALS) : a multicenter retrospective French study

Cerebral Aspergillosis Lesion Study (CEREALS) : a multicenter retrospective French studyConference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Abstract SUMMARYAspergilli produce conidia for reproduction or to survive hostile conditions, and they are highly effective in the distribution of conidia through the environment. In immunocompromised individuals, inhaled conidia can germinate inside the respiratory tract, which may result in invasive pulmonary aspergillosis. The management of invasive aspergillosis has become more complex, with new risk groups being identified and the emergence of antifungal resistance. Patient survival is threatened by these developments, stressing the need for alternative therapeutic strategies. As germination is crucial for in...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Microbiol Mol Biol Rev Source Type: research
CONCLUSION: Surgical pathologists should carefully examine the histological characteristics of the fungus to correctly identify specimens and be able to administer proper therapies. PMID: 31787731 [PubMed - in process]
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
Publication date: Available online 4 December 2019Source: Respiratory Medicine Case ReportsAuthor(s): Fumiya Nihashi, Toshiya Hiramatsu, Tomohiro Uto, Jun Sato, Shiro Imokawa, Takafumi SudaAbstractBronchoscopic findings often show mucoid impaction in patients with allergic bronchopulmonary aspergillosis (ABPA); however, endobronchial mucosal nodular lesions have not been reported. We herein present the first such case of a 52-year-old woman with ABPA with endobronchial mucosal nodular lesions. The endobronchial lesions were located in the orifice of the mucoid impaction, and disappeared after 4 weeks of treatment with pred...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Current suboptimal treatment options of invasive fungal infections and emerging resistance of the corresponding pathogens urge the need for alternative therapy strategies and require the identification of novel antifungal targets. Aspergillus fumigatus is the most common airborne opportunistic mold pathogen causing invasive and often fatal disease. Establishing a novel in vivo conditional gene expression system, we demonstrate that downregulation of the class 1 lysine deacetylase (KDAC) RpdA leads to avirulence of A. fumigatus in a murine model for pulmonary aspergillosis. The xylP promoter used has previously been shown t...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
l;a M Abstract Aspergillosis is a disease of domestic and free-living birds caused by infection with a fraction of fungi within the genus Aspergillus. Species can be identified by colony morphology and microscopic characterization of conidia and conidiophores or by PCR, and isolates can be typed by microsatellite typing. Serodiagnostic options for testing are limited to antibody and antigen detection methods. The sensitivity of these tests can be enhanced through the use of protein electrophoresis. In many countries, no systemic antifungal drugs are registered for use in food-producing animals and resistance to an...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research
Background: Aspergillus lung disease may be associated with either the development of, or complicate, non-cystic fibrosis bronchiectasis (NCFB). Whilst IgE to aspergillus may support a diagnosis of Allergic Bronchopulmonary Aspergillosis, the significance of IgG to aspergillus (IgG asp) in NCFB is unclear.Method: A retrospective case series reviewing 102 patients diagnosed with NCFB, seen in a specialist secondary care bronchiectasis clinic in 2015. 60.8% had a previous IgG asp performed. 16 (25.8%) patients had elevated (≥40mgA/L) IgG asp (high group) and 46 (74.2%) patients had normal (
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Conclusion: ABPA patients have higher levels of sIgG and sIgE of A.fumigatus than SAFS patients. Combination of sIgG and sIgE of A.fumigatus to diagnosis ABPA and SAFS patients is important.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aspergillus (ASP) sensitization is frequent in severe asthma (SA). Aspergillus-associated disease, such as allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) can be associated with bronchiectasis (B). B is a comorbidity in patients with SA. We investigated the prevalence and the characteristics of Aspergillus-associated bronchiectasis in 73 consecutive immunocompetent patients with SA.Methods: All the patients underwent assessment of history, spirometry, FENO, circulating eosinophils (EOS), serum total IgE, IgE-ASP (increased if> 0.10 kUA/L), and IgG-ASP (increased if>40 U/ml), c...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusion: Our results suggest high prevalence of positivity to GM in subjects with IPF. Moreover, these subjects showed a slight improvement in the functional trend with antifungal therapy. Further studies are needed to clarify the potential role of Aspergillus infection in IPF pathogenesis and progression.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Idiopathic interstitial pneumonias Source Type: research
Conclusion: Despite the universal screening for ABPA recommended by the ERS, only 17% were screened for ABPA of which 50% showed evidence of underline ABPA.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: General practice and primary care Source Type: research
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