Interspecies interactions induce exploratory motility in < i > Pseudomonas aeruginosa < /i >

Microbes often live in multispecies communities where interactions among community members impact both the individual constituents and the surrounding environment. Here, we developed a system to visualize interspecies behaviors at initial encounters. By imaging two prevalent pathogens known to be coisolated from chronic illnesses,Pseudomonas aeruginosa andStaphylococcus aureus, we observedP. aeruginosa can modify surface motility in response to secreted factors fromS. aureus. Upon sensingS. aureus,P. aeruginosa transitioned from collective to single-cell motility with an associated increase in speed and directedness - a behavior we refer to as 'exploratory motility'. Explorer cells moved preferentially towardsS. aureus and invadedS. aureuscolonies through the action of the type IV pili. These studies reveal previously undescribed motility behaviors and lend insight into howP. aeruginosa senses and responds to other species. Identifying strategies to harness these interactions may open avenues for new antimicrobial strategies.
Source: eLife - Category: Biomedical Science Tags: Microbiology and Infectious Disease Source Type: research