Australia unprepared to move future Alzheimer's treatment into rapid clinical use

(RAND Corporation) Much work has been done to try to find a treatment that can delay or prevent the onset of Alzheimer's disease, but less attention has been paid to whether health systems could move a breakthrough into rapid clinical use. A new study finds that while Australia is better prepared than many other countries for such a development, there are steps policymakers may consider to better prepare the nation's health system.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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CONCLUSIONS: This study did not support an association between statin use and diagnostic conversion but suggested a possible association between statin use and cognitive change in EMCI. Additional randomized clinical trials of statins may be warranted in the prodromal EMCI stage of AD. PMID: 31806426 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Publication date: 1 January 2020Source: Neuroscience, Volume 424Author(s): Eva-Lotta von Rüden, Christina Zellinger, Julia Gedon, Andreas Walker, Vera Bierling, Cornelia A. Deeg, Stefanie M. Hauck, Heidrun PotschkaAbstractClinical evidence and pathological studies suggest a bidirectional link between temporal lobe epilepsy and Alzheimer’s disease (AD). Data analysis from omic studies offers an excellent opportunity to identify the overlap in molecular alterations between the two pathologies.We have subjected proteomic data sets from a rat model of epileptogenesis to a bioinformatics analysis focused on proteins ...
Source: Neuroscience - Category: Neuroscience Source Type: research
EARLY PREDICTION OF ALZHEIMER'S DISEASE DEMENTIA BASED ON BASELINE HIPPOCAMPAL MRI AND 1-YEAR FOLLOW-UP COGNITIVE MEASURES USING DEEP RECURRENT NEURAL NETWORKS. Proc IEEE Int Symp Biomed Imaging. 2019 Apr;2019:368-371 Authors: Li H, Fan Y, Alzheimer’s Disease Neuroimaging Initiative Abstract Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when and which mild cognitive impairment (MCI) individuals will convert to...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
Authors: Ghadiri-Sani M, Larner AJ Abstract The head turning sign was first described as such more than 20 years ago but only recently have empirical studies of the sign in large cohorts of patients being assessed for cognitive disorders been reported. Although precise operationalisation of the sign has differed between studies, nevertheless it appears to be frequently observed in cognitive clinic patient cohorts, more so in Alzheimer's disease than in other dementias and with an intermediate frequency in mild cognitive impairment. Head turning is an easily observed and categorised sign and may raise suspicion of t...
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Authors: Silverstein NM, Pitheckoff N, Dugan E Abstract Engaging gerontology students in research that hits "close-to-home" can have lasting benefits for them and their communities both professionally and personally. Since 2016, cohorts of undergraduate/certificate students in an online applied research in aging course have explored healthy aging in their Massachusetts' (MA) communities. The students utilized both primary and secondary data sources. First, they extracted data from the 2014-2015 healthy aging data report (HADR) community profiles of 367 MA communities. Then they conducted in-person in...
Source: Gerontology and Geriatrics Education - Category: Geriatrics Tags: Gerontol Geriatr Educ Source Type: research
AbstractPreclinical experiments and clinical trials demonstrated that angiotensin II AT1 receptor overactivity associates with aging and cellular senescence and that AT1 receptor blockers (ARBs) protect from age-related brain disorders. In a primary neuronal culture submitted to glutamate excitotoxicity, gene set enrichment analysis (GSEA) revealed expression of several hundred genes altered by glutamate and normalized by candesartan correlated with changes in expression in Alzheimer ’s patient’s hippocampus. To further establish whether our data correlated with gene expression alterations associated with aging...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Low-dose hydromethylthionine may help prevent both cognitive decline and brain atrophy in early Alzheimer's disease, new exploratory research suggests.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Source Type: news
Conclusion: The evidence from the present study suggests that T allele of CD33 rs3865444 polymorphism is associated with LOAD in the studied Iranian population. PMID: 31799158 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
Spain's Grifols said on Friday the latest results from a clinical trial of its Alzheimer's treatment show positive effects by achieving a reduction of the disease's progression in patients with mild and moderate conditions.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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