Optimized artificial neural network based performance analysis of wheelchair movement for ALS patients

Publication date: Available online 9 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Kai Li, S. Ramkumar, J. Thimmiaraja, S. DiwakaranAbstractIndividuals with neurodegenerative attacks loose the entire motor neuron movements. These conditions affect the individual actions like walking, speaking impairment and totally make the person in to locked in state (LIS). To overcome the miserable condition the person need rehabilitation devices through a Brain Computer Interfaces (BCI) to satisfy their needs. BMI using Electroencephalogram (EEG) receives the mental thoughts from brain and converts into control signals to activate the exterior communication appliances in the absence of biological channels. To design the BCI, we conduct our study with three normal male subjects, three normal female subjects and three ALS affected individuals from the age of 20 to 60 with three electrode systems for four tasks. One Dimensional Local Binary Patterns (LBP) technique was applied to reduce the digitally sampled features collected from nine subjects was treated with Grey wolf optimization Neural Network (GWONN) to classify the mentally composed words. Using these techniques, we compared the three types of subjects to identify the performances. The study proves that subjects from normal male categories performance was maximum compared with the other subjects. To assess the individual performance of the subject, we conducted the recognition accuracy test in offline mode. From ...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research

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Conclusion: There is insufficient evidence to promote any one intervention for the management of UMN-NB. The promotion of DRS, and education as to the proper technique for DRS should remain an emphasis of education of home management of UMN-NB in persons with SCI. Future research should focus on the use of standardized, validated tools to evaluate management techniques for UMN-NB. PMID: 31809250 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Conclusions about the regulation of the MuSK kinase that were derived from molecular structures will be highlighted. In addition, the role of MuSK during development and disease will be discussed.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
AbstractSpinal muscular atrophy (SMA) is a motor neuron disease caused by loss of function mutations in theSurvival Motor Neuron 1 (SMN1) gene and reduced expression of the SMN protein, leading to spinal motor neuron death, muscle weakness and atrophy. Although humans harbour the highly homologousSMN2 gene, its defective splicing regulation yields a truncated and unstable SMN protein. The first therapy for SMA was recently approved by the Food and Drug Administration (FDA) and consists of an antisense oligonucleotide (Nusinersen) renderingSMN2 functional and thus improving patients' motor activity and quality of life. Neve...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
During development, the nervous system undergoes a refinement process by which neurons initially extend an excess number of neurites, the majority of which will be eliminated by the mechanism called neurite pruning. Some neurites undergo stereotyped and developmentally regulated pruning. However, the signaling cues that instruct stereotyped neurite pruning are yet to be fully elucidated. Here we show that Wnt morphogen instructs stereotyped neurite pruning for proper neurite projection patterning of the cholinergic motor neuron called PDB inC. elegans. Inlin-44/wnt andlin-17/frizzled mutant animals, the PDB neurites often ...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Neuroscience Source Type: research
Publication date: 3 December 2019Source: Cell Reports, Volume 29, Issue 10Author(s): Aleksandra Vukojicic, Nicolas Delestrée, Emily V. Fletcher, John G. Pagiazitis, Sethu Sankaranarayanan, Ted A. Yednock, Ben A. Barres, George Z. MentisSummaryMovement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood. Similarly, the molecular mechanisms by which gene mutations cause dysfunction and elimination of synapses in neurodegenerative diseases that occur during development are unknow...
Source: Cell Reports - Category: Cytology Source Type: research
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease that has been linked to defective DNA repair. Many familial ALS patients harbor autosomal dominant mutations in the gene encoding the ...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Micro report Source Type: research
Abstract Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a rare autosomal recessive neuromuscular disorder caused by mutations in the IGHMBP2 gene, which encodes immunoglobulin μ-binding protein 2, leading to progressive spinal motor neuron degeneration. We review the data available in the literature about SMARD1. The vast majority of patients show an onset of typical symptoms in the first year of life. The main clinical features are distal muscular atrophy and diaphragmatic palsy, for which permanent supportive ventilation is required. No effective treatment is available yet, but novel the...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
This report describes the clinical presentation of a female patient diagnosed with crural MMA. Careful clinical correlation is necessary to distinguish crural MMA from other motor neuron diseases. When crural MMA is diagnosed, treatment options aim to alleviate symptoms. AbstractThis report describes the clinical presentation of a female patient diagnosed with crural MMA. Careful clinical correlation is necessary to distinguish crural MMA from other motor neuron diseases. When crural MMA is diagnosed, treatment options aim to alleviate symptoms.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Publication date: Available online 2 December 2019Source: Neuroscience LettersAuthor(s): Mendell RimerAbstractThe neuromuscular junction is the synapse between a motor neuron of the spinal cord and a skeletal muscle fiber in the periphery. Reciprocal interactions between these excitable cells, and between them and others cell types present within the muscle tissue, shape the development, homeostasis and plasticity of skeletal muscle. An important aim in the field is to understand the molecular mechanisms underlying these cellular interactions, which include identifying the nature of the signals and receptors involved but a...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Abstract In this work, we analyze a simplified, dynamical, closed-loop, neuromechanical simulation of insect joint control. We are specifically interested in two elements: (1) how slow muscle fibers may serve as temporal integrators of sensory feedback and (2) the role of common inhibitory (CI) motor neurons in resetting this integration when the commanded position changes, particularly during steady-state walking. Despite the simplicity of the model, we show that slow muscle fibers increase the accuracy of limb positioning, even for motions much shorter than the relaxation time of the fiber; this increase in accu...
Source: Biological Cybernetics - Category: Science Authors: Tags: Biol Cybern Source Type: research
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