Renal thrombotic microangiopathy during nintedanib treatment for idiopathic pulmonary fibrosis 
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We describe a case of a 45-year-old male who presented with isolated proteinuria of 1.3 g/g Cr 3 years after beginning nintedanib treatment. The kidney biopsy revealed histological features consistent with renal TMA. He underwent single lung transplantation 6 months later, which enabled cessation of nintedanib, and, 1 month later, his proteinuria results were negative. Unlike other types of TKIs, the pathological findings of nintedanib-induced nephrotoxicities have been limitedly reported. This is the first case of isolated proteinuria likely caused by nintedanib-induced TMA.
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PMID: 31699213 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - November 7, 2019 Category: Urology & Nephrology Authors: Inoue D, Nishi H, Honda K, Ishii T, Abe H, Sato M, Nangaku M Tags: Clin Nephrol Source Type: research