Potential molecular mechanisms underlying the effect of arsenic on angiogenesis.

Potential molecular mechanisms underlying the effect of arsenic on angiogenesis. Arch Pharm Res. 2019 Nov 07;: Authors: Zhang J, Zhang Y, Wang W, Zhang Z Abstract Arsenic is a potent chemotherapeutic drug that is applied as a treatment for cancer; it exerts its functions through multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progression of many diseases, arsenic is a feasible treatment option for patients with other angiogenic diseases, including rheumatoid arthritis and psoriasis, among others. However, arsenic is also a well-known carcinogen, demonstrating a pro-angiogenesis effect. This review will focus on the dual effects of arsenic on neovascularization and the relevant mechanisms underlying these effects, aiming to provide a rational understanding of arsenic treatment. In particular, we expect to provide a comprehensive overview of the current knowledge of the mechanisms by which arsenic influences angiogenesis. PMID: 31701373 [PubMed - as supplied by publisher]
Source: Archives of Pharmacal Research - Category: Drugs & Pharmacology Authors: Tags: Arch Pharm Res Source Type: research