Multilayered injection of calcium hydroxylapatite filler on ischial soft tissue to rejuvenate the previous phase of chronic sitting pressure sore.

Conclusion: Depressed soft tissue and skin folds on ischial areas were significantly improved by volumization of subdermal filler injection. The skin quality, roughness, and pigmentation on ischial areas improved, and these improvements may be caused by intradermal micro-droplet injections of CaHA filler which may be influenced by neocollagenesis by numerous fibroblasts and increased micro-blood circulation (neovascularization). This is the first article to show the scientific evidence of neocollagenesis and tissue reaction after an injection of CaHA filler in the dermis, especially using various histological staining and to show various stages of inflammation and foreign body reaction around CaHA particles. Numerous fibroblasts were present around CaHA particles, but plasma cells were not found. Interestingly a few eosinophils were found around CaHA filler. After a significant period of time, multi-layered injections of diluted CaHA tightened and remodeled atrophic ischial skin. The multi layered injection approach was safe and effectively treated ischial soft tissue atrophy without significant side effects, such as infection or delayed swelling or lumps. PMID: 31686889 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research