The 5-Hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation.

This study shows that agonism of 5-HT2AR reduces repetitive behavioral patterns, supporting the theory that this is a potential new treatment approach to disorders of cognitive or behavioral inflexibility.
PMID: 31693871 [PubMed - as supplied by publisher]

Source: Neuropharmacology - November 2, 2019 Category: Drugs & Pharmacology Authors: Odland AU, Jessen L, Kristensen JL, Fitzpatrick CM, Andreasen JT Tags: Neuropharmacology Source Type: research