The 5-Hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation.

This study shows that agonism of 5-HT2AR reduces repetitive behavioral patterns, supporting the theory that this is a potential new treatment approach to disorders of cognitive or behavioral inflexibility. PMID: 31693871 [PubMed - as supplied by publisher]
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research

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Youth who are taking antidepressants in the class of serotonin reuptake inhibitors (SSRIs) for anxiety or obsessive compulsive disorder (OCD) are more likely to experience side effects that cause them to discontinue the medication than those taking serotonin-norepinephrine inhibitors (SNRIs), according to a report in theJournal of the American Academy of Child and Adolescent Psychiatry.SSRIs also appear to be more commonly associated with “activation syndrome”—a cluster of symptoms including restlessness, anxiety, and agitation.Both classes of antidepressants are commonly prescribed for young people with ...
Source: Psychiatr News - Category: Psychiatry Tags: Journal of the American Academy of Adolescent Psychiatry medications for youth with anxiety and OCD selective serotonin reuptake inhibitor side effects SNRIs treatment discontinuation Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Or Brandes, Avital Stern, Guy DoronAbstractRelationship Obsessive–compulsive disorder (ROCD) is a dimension of Obsessive–compulsive disorder (OCD) focusing on close and intimate relationships. ROCD may focus on the relationship itself (i.e., relationship-centered) or the perceived flaws of the relationship partner (i.e., partner-focused). Partner-focused obsessions have been shown to center on domains such as intelligence, appearance, sociality, emotional regulation, competence and morality....
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
ConclusionsRumination is known to be associated with poor prognosis in mental health. This study suggests that rumination is a maladaptive coping style associated not only with worry, distress and illness severity, but also with socioeconomic status. Also, rumination demonstrated a specific association with panic disorder.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Conclusions: Our data are in accordance with previous findings outlining that N + insomniacs have higher PSQI scores than N-. Our results do not confirm the suggested association between napping and depressive or obsessive-compulsive symptoms. Conversely, we found a statistically significant difference (p = 0.0014) in EAT scores in N + and N-. Hyperarousal and REM sleep instability in insomniac patients may create an unbalance of the neuroendocrine hypothalamic regulation leading to an appetite alteration. PMID: 31790624 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
CONCLUSIONS: Obsessive-compulsive symptoms are common in persons with epilepsy and are associated with severe epilepsy, temporal lobe seizures, and the use of topiramate and lamotrigine. Specifically, the use of lamotrigine may aggravate OCS, whereas the use of topiramate may have beneficial effects on OCS. PMID: 31805509 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
amy Subramaniam This is a preliminary study to examine the factor structure, reliability, and validity of an obsessive-compulsive disorder (OCD) screening tool for use in the Malaysian setting. A total of 199 Malaysian adults were recruited for this study. After cleaning and normalizing the data, 190 samples were left to be analyzed. Principle component analysis using varimax rotation was then performed to examine various factors derived from psychometric tools commonly used to assess OCD patients. The screening tool exhibited three factors that fit the description of obsessions and compulsions from the Diagnostic and ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This article is intended to provide an overview of the literature regarding mental disorders associated with polycystic ovary syndrome and to present own research on depression and sexual dysfunction in this group. PMID: 31760419 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Beszłej JA, Siwicki D, Fila-Witecka K, Wieczorek T, Piotrowski P, Weiser A, Tabakow P, Rymaszewska J Abstract Obsessive-compulsive disorder (OCD) occurs in 2-3% of the general population. Due to its chronicity and high resistance to standard treatment, alternative clinical management based on neuroscientific findings has been sought. Deep brain stimulation (DBS) is a modern and dynamic approach in the treatment of OCD giving hope to patients who are resistant to current pharmacotherapy and psychotherapy based treatments. This paper presents two cases of patients diagnosed with refractory OCD who received ...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: The remission of the patient suggested that CCT could be an alternative intervention for treatment-refractory OCD and those with severe OCD could be cured in short-term. PMID: 31756555 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
We examined (a) moderation effects of anxiety, depression, psychological inflexibility, and interpretation of intrusions and (b) the role of psychological inflexibility and interpretation of intrusions respectively as processes of change. Participants with less dysfunctional appraisals at pretreatment performed consistently better in ERP relative to ACT + ERP. In process analyses, psychological inflexibility and interpretation of intrusions positively influenced OCD severity over time in both conditions but OCD symptom severity also positively influenced psychological inflexibility and interpretation of intrusion...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
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