Evaluating prognostic utility of preoperative Neutrophil to Lymphocyte Ratio and hsa-let-7g/c up-regulation in patients with urinary bladder cancer.

CONCLUSIONS: Our data demonstrated the potential clinical value of all markers, especially pretreatment NLR and let-7g. Further studies are recommended to confirm their utility in improving the clinical decision-making regarding treatment and follow-up scheduling. PMID: 31683460 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

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CONCLUSION: Hyperthermic Mitomycin using the HIVEC® device is a rather safe and well tolerated treatment. Efficiency remains partial as 27.3% of patients experienced recurrence during the first year. These data should be confirmed by prospective multicentric studies. PMID: 31787540 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Two common beauty products—permanent hair dyes and chemical straighteners—may be associated with an elevated risk for breast cancer, according to a new study published in the International Journal of Cancer. Hair dyes have been linked to other cancers before, though the research is inconclusive. Bladder and blood cancers have been examined most closely, according to the American Cancer Society, with the most consistent results pointing to a small increase in bladder cancer risk for salon employees. Meanwhile, most studies to date looking specifically at dye and breast cancer have not found a connection. The pic...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer Source Type: news
Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN metastasis in BCa. However, approximately 20% of BCa with LN metastasis exhibits low VEGF-C expression, suggesting a VEGF-C–independent mechanism for LN metastasis of BCa. Herein, we demonstrate that BCa cell–secreted exosome-mediated lymphangiogenesis promoted LN metastasis in BCa in a VEGF-C–independent manner. We identified an exosomal long noncoding RNA (lncRNA), termed lymph node metastasis-associated transcript 2 (LNMAT2), that stimulate...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): Teymur Musayev
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): Sh. Chovelidze, L. Gofodze, N. Lomidze, G. Burkadze, B. Sibashvili, L. Donadze, V. Beridze, V. Sadikov
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): David Nikoleishvili, Givi Koberidze, Zaza Tchanturaia
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Purpose of review To summarize recent publications on the topic of laser in urology and explore new developments which may impact the future role of lasers in surgery. Recent findings Ho: Yttrium-aluminium garnet (YAG) laser with Moses technology allows less retropulsion during a lithotripsy, yet its efficacy needs to be tested in clinical trials. Data on the efficacy of this device for benign prostatic obstruction treatment is also pending. A new promising generation of laser systems – thulium-fiber (Tm-fiber) lasers – has been introduced. Tm-fiber has already been shown to be effective and well tolerated...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: BEST OF 2019: Edited by Johannes W. Vieweg and Shahrokh F. Shariat Source Type: research
Purpose of review Conventional transurethral resection of bladder tumor (cTURBT) is the standard approach to the diagnosis and treatment of nonmuscle invasive bladder cancer. However, it suffers from inherent limitations such as insufficient assessment of resection depth and the need for intravesical tumor fragmentation that hampers histopathological evaluation. We summarize recent clinical data on en bloc resection of bladder tumor (ERBT), a method that promises to overcome these limitations. Recent findings The PubMed/Medline databases were searched for reports on ERBT focusing on trends in the last 2 years. ERBT pr...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: BEST OF 2019: Edited by Johannes W. Vieweg and Shahrokh F. Shariat Source Type: research
Cell Death &Differentiation, Published online: 04 December 2019; doi:10.1038/s41418-019-0466-7GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer
Source: Cell Death and Differentiation - Category: Cytology Authors: Source Type: research
This study aims to explore the relation of USP28 with tumor growth and invasion, and also to investigate the interplay between USP28 and p53 in BCa. Expression levels of USP28 and p53 in human BCa (invasive and non-invasive, n = 43) and control tissues (n = 8) were evaluated by immunohistochemistry and quantitative real-time polymerase chain reaction (qPCR) profiling. The relationship between protein and gene expression levels, clinicopathologic features and prognosis were evaluated. Significant positive correlations were found between BCa tumor progression and the USP28 expression, and also bet...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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