PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats

Conclusions and ImplicationsA system‐specific model characterizing the interrelationship between BP, CO and TPR was obtained, which can be used to quantify and predict the cardiovascular effects of a drug and to elucidate the MoA for novel compounds. Ultimately, the proposed PKPD model could be used to predict the effects of a particular drug on BP in humans based on preclinical data.

Source: British Journal of Pharmacology - July 12, 2013 Category: Drugs & Pharmacology Authors: N Snelder, B A Ploeger, O Luttringer, D F Rigel, R L Webb, D Feldman, F Fu, M Beil, L Jin, D R Stanski, M Danhof Tags: Research Paper Source Type: research