Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via PI3K/Akt/NF- κB Signaling Pathway in Subarachnoid Hemorrhage Cell Model

Tenascin-C (TNC) is upregulated in serum and cerebrospinal fluid after subarachnoid hemorrhage (SAH) and the deficiency of TNC could alleviate neuronal apoptosis and neuroinflammation after SAH. However, the specific mechanism of TNC regulating neuronal apoptosis and neuroinflammation after SAH is not well recognized. The aim of this study was to investigate whether PI3K/Akt/ NF- κB signaling pathway is involved in the regulation of TNC on early brain injury after SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research