Beneficial effects of baicalein on a model of allergic rhinitis.

This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.
PMID: 31677374 [PubMed - in process]

Source: Acta Pharmaceutica - November 6, 2019 Category: Drugs & Pharmacology Authors: Liu T, Xu J, Wu Y, Li X, Ding D, Ma D, Yao M, Wei W, Zhang W, Wang S, Yao J, Li X Tags: Acta Pharm Source Type: research