Computational quantification of patient specific changes in ventricular dynamics associated with pulmonary hypertension.

Computational quantification of patient specific changes in ventricular dynamics associated with pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2019 Nov 01;: Authors: Finsberg HNT, Sundnes JS, Xi C, Lee LC, Zhao X, Tan JL, Genet M, Zhong L, Wall ST Abstract Pulmonary arterial hypertension causes an increase in the mechanical loading imposed on the right ventricle that results in progressive changes to its mechanics and function. Here, we quantify the mechanical changes associated with PAH by assimiliating clinical data consisting of reconstructed 3D geometry, pressure and volume waveforms as well as regional strains measured in PAH patients (n = 12) and controls (n = 6) within a computational modeling framework of the ventricles. Modeling parameters reflecting regional passive stiness and load-independent contractility as indexed by the tissue active tension were optimized so that simulation results matched the measurements The optimized parameters were compared with clinical metrics to and usable indicators associated with the underlying mechanical changes. Peak contractility of the RV free wall γRWFW,max was found to be strongly correlated, and had an inverse relationship with the RV and left ventricle end-diastolic volume ratio (i.e., RVEDV/LVEDV) (γRWFW,max=-0.13(RVEDV/LVEDV)+0.44, R2=0.77). Correlation with RV ejection fraction (R2=0.5) and end-diastolic volume index (R2=0.4) were comparatively weaker. Patients with ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research