Anti-tuberculosis (TB) chemotherapy dynamically rescues Th1 and CD8+ T effector levels in Han Chinese pulmonary TB patients

Publication date: Available online 1 November 2019Source: Microbes and InfectionAuthor(s): Guobao Li, Fang Yang, Xing He, Zhi Liu, Jiang Pi, Yuzhen Zhu, Xue Ke, Shuyan Liu, Min Ou, Huixin Guo, Zhuoran Zhang, Gucheng Zeng, Guoliang ZhangAbstractCD4+/CD8+ T cells play a major role in conferring immune protection against tuberculosis (TB), but it remains unknown how the immune responses of CD4+/CD8+ T cells exactly correlate with the clinical variables and disease statuses during anti-TB chemotherapy. To address this, several major immune parameters of CD4+/CD8+ T cells in peripheral blood derived from pulmonary TB patients and healthy volunteers were evaluated. We observed that active TB infection induced lower CD3+ T cell and CD4+ T cell levels but higher CD8+T cell levels, while anti-TB chemotherapy reversed these effects. Also, anti-TB treatment induced enhanced production of IL-2 and IFN-γ but reduced expression of IL-10 and IL-6. Moreover, the dynamic changes of CD3, CD4, and CD8 levels did not show a significant association with sputum smear positivity. However, the frequencies of IL-2+CD4+ or IL-10+CD4+ T effector subpopulation or IL-1β production in peripheral blood showed significant difference between patients positive for sputum smear and patients negative for sputum smear after anti-TB treatment.These findings implicated that recovery of Th1/CD8+T cell effector levels might be critical immunological events in pulmonary TB patients after treatment and furt...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research

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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Thoracic surgery Source Type: research
The aim of our study was to investigate the effectiveness of intravenous (i/v) isoniazid (H) and ethambutol (E) administration in patients with new smear positive drug-susceptible pulmonary TB with TB meningoencephalitis(TM) and HIV co-infection in the intensive phase of treatment.Material and Methods: 54 patients with TB/TM and HIV co-infection were enrolled in this study. Group1 included 23 patients with TB/TM and HIV co-infection treated with E and H i/v, while rifampicin and pyrazinamide were prescribed orally. The group 2 consisted of 31 patients–treated with 1st-line anti-TB drugs orally. Concentrations of H an...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Conclusions: The use of Bedaklivin in patients with a combination of tuberculosis and HIV infection increases the effectiveness of therapy to stop bacterial release in a shorter time to 2m months. The incidence of adverse reactions in this group of patients does not differ significantly from the control group.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
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Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine Genexpert meningitis TB TB meningitis Tuberculosis Source Type: blogs
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