Cigarette Smoke exposure Alters Phosphodiesterases in Human Structural Lung Cells.

This study reveals that chronic CS exposure modulates the expression of various PDE members. Thus, CS exposure may change the levels of intracellular cyclic nucleotides and thereby impact the efficiency of PDE-targeted therapies.
PMID: 31664853 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - October 29, 2019 Category: Cytology Authors: Zuo H, Faiz A, van den Berge M, Mudiyanselage SNHR, Borghuis T, Timens W, Nikolaev VO, Burgess JK, Schmidt M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research