Molecular signature of interleukin-22 in colon carcinoma cells and organoid models

Interleukin (IL)-22 activates STAT (signal transducer and activator of transcription) 3 and anti-apoptotic and pro-proliferative pathways; but beyond this, the molecular mechanisms by which IL-22 promotes carcinogenesis are poorly understood.Characterizing the molecular signature of IL-22 in human DLD-1 colon carcinoma cells, we observed increased expression of 26 genes, including NNMT (nicotinamide N-methyltransferase, ≤10-fold) and CEA (carcinoembryonic antigen, ≤7-fold), both known to promote intestinal carcinogenesis.

Source: Translational Research - October 31, 2019 Category: Research Authors: Ina Rudloff, Thierry Jarde, Malte Bachmann, Kirstin D. Elgass, Genevieve Kerr, Rebekah Engel, Elizabeth Richards, Karen Oliva, Simon Wilkins, Paul J. McMurrick, Helen E. Abud, Heiko M ühl, Marcel F. Nold Source Type: research