Radiotherapy-induced xerostomia: a randomised, double-blind, controlled trial of Visco-ease ™ oral spray compared with placebo in patients with cancer of the head and neck

Radiotherapy-induced xerostomia (RIX) is a common and untreatable side effect of radiotherapy to the head and neck. Visco-ease ™ mouth spray (Lamellar Biomedical Ltd), a new product that is made from lamellar body mimetics, reduces the viscosity of saliva ex vivo. The purpose of this study was to evaluate its safety and effectiveness in the treatment of RIX in 43 patients with cancer of the head and neck. They were random ised into the Visco-ease™ or placebo groups, and asked to complete the Groningen radiotherapy-induced xerostomia (GRIX) questionnaire each week.

Source: The British Journal of Oral and Maxillofacial Surgery - October 28, 2019 Category: ENT & OMF Authors: C. Paterson, M.C. Thomson, B. Caldwell, R. Young, A. McLean, S. Porteous, S. Clark, C.M. Messow, S. Kean, D. Grose, C. Lamb, M. Rizwannullah, A. James, S. Schipani, C. Wilson, R. Rulach, R. Jones Source Type: research