Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders.

Salivary Pepsin as an Intrinsic Marker for Diagnosis of Sub-types of Gastroesophageal Reflux Disease and Gastroesophageal Reflux Disease-related Disorders. J Neurogastroenterol Motil. 2019 Oct 25;: Authors: Wang YJ, Lang XQ, Wu D, He YQ, Lan CH, Xiao X, Wang B, Zou DW, Wu JM, Zhao YB, Dettmar PW, Chen DF, Yang M Abstract Background/Aims: To determine the value of salivary pepsin in discriminating sub-types of gastroesophageal refluxdisease (GERD) and GERD-related disorders. Methods: Overall, 322 patients with different sub-types of GERD and 45 healthy controls (HC) werestudied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) andunderwent endoscopy and 24-hour esophageal pH monitoring and manometry. Salivary pepsinconcentration (SPC) was detected by using colloidal gold double-antibody immunologicalsandwich assay. Oral esomeprazole treatment was administrated in the patients with non-erosivereflux disease (NERD) and extra-esophageal symptoms (EES). Results: Compared to HC, patients with erosive esophagitis, NERD, EES, EES plus typical GERDsymptoms, or Barrett's esophagus had a higher prevalence of saliva and SPC (all P
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

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