Enantioselective LC Analysis and Determination of Selective Serotonin Reuptake Inhibitors (SSRIs).

Enantioselective LC Analysis and Determination of Selective Serotonin Reuptake Inhibitors (SSRIs). Biomed Chromatogr. 2019 Oct 25;:e4730 Authors: Sethi S, Bhushan R Abstract LC separation of biologically and pharmaceutically important enantiomers (from racemic or non-racemic mixtures) remains the subject of importance. The present review article deals with the liquid chromatographic enantioseparation of chiral SSRIs namely, citalopram, paroxetine, sertraline, and fluoxetine. It is now known that the enantiomers of numerous psychotropic drugs exhibit distinct pharmacodynamics and pharmacokinetic patterns and receptor binding properties, and psychiatric patients are frequently taking more than one medication. Therefore, monitoring of the levels of these analytes in biological fluids becomes important to determine the levels of enantiomer concentrations; the present paper may be helpful in understanding the present state of available methods (along with a critical discussion of applicability of the methods) and in developing the new ones, for this purpose. Different approaches using LC, discussed herein, may be applied for determining enantiomeric composition (and enantiomeric purity) of SSRIs and numerous other racemic drugs, of current/future, pharmaceutical importance and utility, using simple separation methods, instrumentation, inexpensive reagents and potentially significant analytical approaches. The contents cover the essential ...
Source: Biomedical Chromatography : BMC - Category: Biomedical Science Authors: Tags: Biomed Chromatogr Source Type: research