[Comment] Oseltamivir resistance during treatment of H7N9 infection

Detection of an Arg292Lys mutation (N2 numbering) in the virus neuraminidase (NA) gene within 2 days of initiating oseltamivir treatment, in the first reported human infection by avian A(H7N9) influenza virus, raised concern about emergence of resistance during treatment with neuraminidase inhibitors. This is important because a Ser31Asn resistance mutation in the M2 protein of A(H7N9) viruses, also present in A(H1N1)pdm09 and seasonal A(H3N2) viruses, abrogates effectiveness of available M2 inhibitors (amantadine and rimantadine).
Source: LANCET - Category: Journals (General) Authors: Tags: Comment Source Type: research