Antiproliferative evaluation of various aminoquinoline derivatives.

Antiproliferative evaluation of various aminoquinoline derivatives.
Acta Pharm. 2019 Dec 01;69(4):661-672
Authors: Zorc B, Rajić Z, Perković I
Abstract
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a-f, primaquine bis-ureas 2a-f, chloroquine fumardiamides 3a-f and mefloquine fumardiamides 4a-f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.
PMID: 31639093 [PubMed - in process]

Source: Acta Pharmaceutica - October 23, 2019 Category: Drugs & Pharmacology Authors: Zorc B, Rajić Z, Perković I Tags: Acta Pharm Source Type: research