Individual evaluation of luteinizing hormone in aged C57BL/6  J female mice

This study shows that female mice in regular environmental conditions disp lay stable LH surge timing and amplitude up to 9 months, but at 12 months, the LH surge is delayed with a reduced amplitude, however without overt modification in the estrous cycles. Analysis of individual preovulatory LH secretion and estrous cycle indicates that mice can be followed up to 9 mon ths to investigate the detrimental effects of various parameters on mouse reproductive activity.
Source: AGE - Category: Geriatrics Source Type: research