Regulatory T cells induce CD4 − NKT cell anergy and suppress NKT cell cytotoxic function

ConclusionTregs exert suppressive effects on NKT cell tumoricidal function by inducing more CD4− NKT cell anergy and less CD4+ NKT cell anergy. Both Treg depletion and NKT cell recovery from the anergy state may be important for improving the clinical efficacy of NKT cell-based immunotherapy in patients with advanced cancers.

http://link.springer.com/10.1007/s00262-019-02417-6

Source: Cancer Immunology, Immunotherapy - October 21, 2019 Category: Cancer & Oncology Source Type: research