Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system.

In conclusion, ROS may induce the mRNA expression of nuclear receptors and promote the transcription of drug-metabolizing enzymes in the in vitro model of APAP-induced hepatotoxicity. PMID: 31631733 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31631733?dopt=Abstract

Source: Xenobiotica - October 20, 2019 Category: Research Authors: Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K Tags: Xenobiotica Source Type: research