Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells.
Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells.
Anaerobe. 2019 Oct 17;:102112
Authors: Pathmanathan SG, Lawley B, McConnell M, Baird MA, Tannock GW
Abstract
Immuno-modulatory effects of infant gut bacteria were tested on poly(I:C) stimulated HT-29 intestinal epithelial cells. Blautia producta, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides thetaiotaomicron decreased transcription of poly(I:C)-induced inflammatory genes. Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.
PMID: 31629806 [PubMed - as supplied by publisher]
Source: Anaerobe - Category: Microbiology Authors: Pathmanathan SG, Lawley B, McConnell M, Baird MA, Tannock GW Tags: Anaerobe Source Type: research