18F-FDG PET/CT or PET role in MALT lymphoma: an open issue not yet solved. A criticalreview

Publication date: Available online 19 October 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Domenico Albano, Rexhep Durmo, Giorgio Treglia, Raffaele Giubbini, Francesco BertagnaABSTRACTMucosa associated lymphoid tissue (MALT) lymphoma is a lymphoma involving the mucosa-associated lymphoid tissue potentially arising from any mucosal site with stomach as most common site of involvement. MALT lymphoma is usually a not aggressive disease with good prognosis except of selected cases. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a non-invasive imaging tool used for staging, restaging and evaluation of treatment response innon-Hodgkin and Hodgkin lymphoma, but its effective role in MALT lymphoma is yet unclear. The open question is if these lymphomas are 18F-FDG avid or not with conflicting results present in literature and consequently the possible clinical role of 18F-FDG PET/CT in staging and restaging purposes is under debate. The aim of this review is to analyze published data about the role of 18F-FDG PET or PET/CT in patients affected by MALT lymphoma. A comprehensive computer literature search of the Scopus, Cochrane, PubMed/MEDLINE and Embase databases was conducted including articles published up to August 2019; 32 studies analyzing 18F-FDG PET or PET/CT in patients with MALT lymphoma were included. We analyzed the metabolic behaviour of MALT lymphoma at 18F-FDG PET and the impact of PET in staging, trea...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research