Pharmacokinetics and intraocular pressure-lowering activity of TAK-639, a novel C-type natriuretic peptide analog, in rabbit, dog, and monkey.

In conclusion, in rabbit, dog, and monkey, a single topical ocular drop of TAK-639 had a significant IOP-lowering effect that correlated well with increases in TAK-639 levels in aqueous humor and resulted in minimal systemic exposure of TAK-639. PMID: 31626797 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31626797?dopt=Abstract

Source: Experimental Eye Research - October 14, 2019 Category: Opthalmology Authors: Savinainen A, Prusakiewicz JJ, Oswald J, Spencer E, Lou Z, Cohen ML, Rashidzadeh H, Josiah S Tags: Exp Eye Res Source Type: research