Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Epilepsy Patients in Thailand

ConclusionPrescribing extended-release phenytoin showed the lowest total budget impact in Thailand. A healthcare policy recommendation developed from this research would help in solving the antiepileptic drug issue.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research

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Publication date: Available online 17 September 2020Source: Stem Cell ResearchAuthor(s): Huifang Zhao, Lang He, Hualin Huang, Shuai Li, Na Cheng, Feng Tang, Xiaobo Han, Zuoxian Lin, Rongqi Huang, Peng Zhou, Sihao Deng, Jufang Huang, Zhiyuan Li
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Our weekly round-up of the best psychology coverage from elsewhere on the web You’ve probably heard of ASMR — or maybe experienced it yourself from watching videos of people doing things like whispering or rustling paper. But although such videos are incredibly popular, there have been surprisingly few studies on the phenomenon. Giulia Poerio explores what the research has revealed so far at The Conversation. The feelings of “dissociation” caused by drugs like ketamine seem to be related to slow, rhythmic firing patterns of brain cells in an area called the retrosplenial cortex. Research...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Weekly links Source Type: blogs
Alternating hemiplegia of childhood (AHC) (MIM 104290) is characterized by transient repeated attacks of paresis on either or both sides of the body, oculomotor and autonomic abnormalities, movement disorders, and cognitive impairment. Preventing paroxysmal attacks, such as paresis and spasm, in patients with AHC is often difficult. An 8-month-old girl presented to our institution with intractable epilepsy. She developed AHC, with left-right alternating or bilateral recurrent plegia upon waking, involuntary movements, eye movement abnormalities, and psychomotor retardation. She had a heterozygous de novo p.E815K mutation i...
Source: Case Reports in Neurology - Category: Neurology Source Type: research
Conclusions: Routine seizure histories are not standardized. The use of a questionnaire goes a long way in improving semiology description in a low-resource setting and guides the health provider on what details to focus on. The use of epilepsy questionnaires should, therefore, be considered to improve semiology, especially in nonspecialist settings. PMID: 32934658 [PubMed - in process]
Source: Journal of Environmental and Public Health - Category: Environmental Health Tags: J Environ Public Health Source Type: research
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
The EAG (ether-à-go-go) family of voltage-gated K+ channels are important regulators of neuronal and cardiac action potential firing (excitability) and have major roles in human diseases such as epilepsy, schizophrenia, cancer, and sudden cardiac death. A defining feature of EAG (Kv10–12) channels is a highly conserved domain on the N terminus, known as the eag domain, consisting of a Per–ARNT–Sim (PAS) domain capped by a short sequence containing an amphipathic helix (Cap domain). The PAS and Cap domains are both vital for the normal function of EAG channels. Using heme-affinity pulldown assays an...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Protein Structure and Folding Source Type: research
Activity-dependent persistent changes in neuronal intrinsic excitability and synaptic strength are widely thought to underlie learning and memory. Voltage-gated KCNQ/Kv7 potassium channels have been of great interest as the potential targets for memory disorders due to the beneficial effects of their antagonists in cognition. Importantly, de novo dominant mutations in their neuronal subunits KCNQ2/Kv7.2 and KCNQ3/Kv7.3 are associated with epilepsy and neurodevelopmental disorder characterized by developmental delay and intellectual disability. The role of Kv7 channels in neuronal excitability and epilepsy has been extensiv...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Photosensitive epilepsies comprise a broad group of epilepsies in which seizures are provoked by light or pattern stimulation. Photosensitive seizures are the commonest type of reflex seizures which have been reported in 3-5% of all epilepsies. [1,2] Photosensitivity is defined as the presence of photoparoxysmal response(PPR) to intermittent photic stimulation (IPS) during EEG recording. The most commonly used classification system divides PPR into four different grades (Table 1) ranging from localized occipital spikes or spike-wave discharges (Grade I) to generalized spike or polyspike wave discharges (Grade IV, Fig.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
The publisher regrets that the following errors are present in the published article:
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Erratum Source Type: research
Conclusion: The current evidence suggests that there is insufficient evidence for recommending HM for TBI in clinical practice. Therefore, further larger, high-quality, rigorous RCTs should be conducted.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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