Live Confocal Tissue Assessment With SYTO16/PI and WGA Staining Visualizes Acute Organ Damage and Predicts Delayed Graft Function in Kidney Transplantation

Conclusions: Our data demonstrate that RTCA is feasible and clinically meaningful. The RTCA score predicts DGF and is a valid option to be applied in renal transplantation.
Source: Annals of Surgery - Category: Surgery Tags: ESA PAPERS Source Type: research

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CONCLUSIONS: Anesthetic preconditioning is a promising strategy to prevent I-R injury associated with transplantation. Our results suggest that sirtuin 2 is involved in the protective mechanisms of some commonly used anesthetics against I-R damage. PMID: 31726818 [PubMed - as supplied by publisher]
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
(University of Illinois at Chicago) Researchers report that among patients with obesity, robotic kidney transplants produce survival outcomes comparable to those seen among nonobese patients. The study includes data collected over 10 years from more than 230 robotic-assisted kidney transplants in patients with obesity.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We report an optic atrophy spectrum disorder, including retinal macular dystrophy and kidney insufficiency leading to transplantation, associated with mitochondrial DNA (mtDNA) depletion without accumulation of multiple deletions. By whole-exome sequencing, we identified mutations affecting the mitochondrial single-strand binding protein (SSBP1) in 4 families with dominant and 1 with recessive inheritance. We show that SSBP1 mutations in patient-derived fibroblasts variably affect the amount of SSBP1 protein and alter multimer formation, but not the binding to ssDNA. SSBP1 mutations impaired mtDNA, nucleoids, and 7S-DNA am...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Letter by Moris et al Regarding Article, "Effects of Arteriovenous Fistula Ligation on Cardiac Structure and Function in Kidney Transplant Recipients". Circulation. 2019 Nov 19;140(21):e802-e803 Authors: Moris D, Karachaliou GS, Tsilimigras DI PMID: 31738601 [PubMed - in process]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Letter by Reddy et al Regarding Article, "Effects of Arteriovenous Fistula Ligation on Cardiac Structure and Function in Kidney Transplant Recipients". Circulation. 2019 Nov 19;140(21):e804-e805 Authors: Reddy YNV, Nath KA, Borlaug BA PMID: 31738600 [PubMed - in process]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Response by Rao et al to Letter Regarding Article, "Effects of Arteriovenous Fistula Ligation on Cardiac Structure and Function in Kidney Transplant Recipients". Circulation. 2019 Nov 19;140(21):e806-e807 Authors: Rao NN, McDonald SP, Worthley MI, Coates PT PMID: 31738596 [PubMed - in process]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Conditions:   Transplant;Failure,Kidney;   Transplant; Failure, Pancreas;   Rejection Acute Renal;   Rejection Acute Pancreas Intervention:   Diagnostic Test: dd-cfDNA Blood Test Sponsors:   University of Maryland, Baltimore;   University of Wisconsin, Madison;   Georgetown University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Replacement of azathioprine with mycophenolate mofetil for kidney transplantation was a very costly move, with no discernible benefits in the era of modern immunosuppression, say authors of ATHENA.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nephrology News Source Type: news
Conclusions: Total and free plasma prednisolone measurements correlated poorly with saliva measurements; however, correlation improved when concentrations early in the dosing interval were excluded.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Short Communication Source Type: research
The association between trough blood concentration and systemic exposure of tacrolimus: Comparison between once-daily (Advagraf®) and twice-daily (Prograf®) formulation in de novo kidney transplant recipients. Drug Metab Pharmacokinet. 2019 Oct 21;: Authors: Sukkha S, Chindavijak B, Nosoongnoen W, Phakdeekitchareon B, Kitiyakara C, Sumethkul V Abstract Available data of early conversion from twice-daily tacrolimus (TAC-BID) to once-daily tacrolimus (TAC-OD) in de novo kidney transplant (KT) recipients are limited. We conducted a prospective study of early conversion to TAC-OD in de novo KT reci...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
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