Emergence of a hybrid plasmid derived from IncN1-F33:A −:B− and mcr-1-bearing plasmids mediated by IS26

ConclusionsTo our knowledge, this is the first report of the IS26-mediated fusion of an IncN1-F33:A −:B− plasmid and anmcr-1-carrying phage-like plasmid, providing evidence for the important role of IS26 in the recombination of plasmids. The biological advantages of the fusion plasmid indicated that the fusion event presumably plays a potential role in the dissemination ofmcr-1.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research