Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1

ConclusionsThis is the first study demonstrating a unique markerless deletion ofmcr-1 in a clinical polymyxin-resistantK. pneumoniae. The current polymyxin B dosage regimens are suboptimal againstK. pneumoniae, regardless ofmcr, and can lead to the emergence of resistance.

https://academic.oup.com/jac/article/74/11/3190/5593743?rss=1

Source: Journal of Antimicrobial Chemotherapy - July 31, 2019 Category: Microbiology Source Type: research