Viruses, Vol. 11, Pages 960: Yellow Fever: Integrating Current Knowledge with Technological Innovations to Identify Strategies for Controlling a Re-Emerging Virus

Viruses, Vol. 11, Pages 960: Yellow Fever: Integrating Current Knowledge with Technological Innovations to Identify Strategies for Controlling a Re-Emerging Virus Viruses doi: 10.3390/v11100960 Authors: Robin D.V. Kleinert Eduardo Montoya-Diaz Tanvi Khera Kathrin Welsch Birthe Tegtmeyer Sebastian Hoehl Sandra Ciesek Richard J.P. Brown Yellow fever virus (YFV) represents a re-emerging zoonotic pathogen, transmitted by mosquito vectors to humans from primate reservoirs. Sporadic outbreaks of YFV occur in endemic tropical regions, causing a viral hemorrhagic fever (VHF) associated with high mortality rates. Despite a highly effective vaccine, no antiviral treatments currently exist. Therefore, YFV represents a neglected tropical disease and is chronically understudied, with many aspects of YFV biology incompletely defined including host range, host–virus interactions and correlates of host immunity and pathogenicity. In this article, we review the current state of YFV research, focusing on the viral lifecycle, host responses to infection, species tropism and the success and associated limitations of the YFV-17D vaccine. In addition, we highlight the current lack of available treatments and use publicly available sequence and structural data to assess global patterns of YFV sequence diversity and identify potential drug targets. Finally, we discuss how technological advances, including real-time epidemiological monitoring of outbreaks using next-ge...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research

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Review recent changes in ACIP's recommendations for pneumococcal conjugate vaccine use in older adults.Morbidity &Mortality Weekly Report
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Conclusion: The 2017 dengue outbreak occurred in a larger scale than in the previous years in terms of time, location, and number of patients. More elderly patients were infected by dengue in this outbreak, and this may contribute to the mortality rate. Clinical manifestations of dengue patients in Southern Vietnam are more typical than the northern, but the rate of severe dengue is not different. The mortality risk and underlying conditions associated with dengue-infected elderly patients are worthy of further investigations in the future. PMID: 31815129 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Qishuo Wang, Tianzeng Fu, Xincang Li, Qian Luo, Jinjing Huang, Yongcan Sun, Xuepeng WangAbstractStreptococcus agalactiae and Streptococcus iniae are major bacterial pathogens of tilapia that can cause high mortality concomitant with large economic losses to aquaculture. Although development of vaccines using formalin-killed bacteria to control these diseases has been attempted, the mechanism of immunity against streptococcal infections and the cross-protective ability of these two bacteria remains unclear. To explore the imm...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Agriculture Bird flu Health Science Society UK news Source Type: news
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