Patient's Perspectives of Experimental HCV-Positive to HCV-Negative Renal Transplantation: Report from a Single Site.

Conclusions: Recipients of experimental HCV D+/R- transplants generally seemed to recognize the risks and benefits of these novel transplants and did not regret participating. Such salutary reported experiences are important in assessing the appropriateness of further research into the feasibility of HCV D+/R- transplants. PMID: 31618112 [PubMed - as supplied by publisher]
Source: AJOB Primary Research - Category: Medical Ethics Tags: AJOB Empir Bioeth Source Type: research

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Authors: Sobrinho G, Ministro A, Silva A, Pedro L Abstract Renal artery aneurysms are rare. They are most commonly degenerative, congenital or due to medial fibroplasia. Proximal aneurysms can be repaired by endovascular and in-situ surgical techniques. However, aneurysms of the distal renal artery and its branches require ex-vivo surgical repair, also known as auto-transplantation: the kidney is removed, dissected and reconstructed in cold ischemia, and put back in place. A 69-year-old woman, with hypertension, presented with bilateral renal artery aneurysms with a diameter of 3.4 cm on the rig...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
We report a series of 5 solid organ transplantation recipients diagnosed with STEC-HUS between January 2017 and March 2019 in 2 French nephrology centers (Table 1). One patient had 2 episodes of STEC-HUS. All had severe acute kidney injury (requiring hemodialysis in 2). Neurological involvement was noted during 5 episodes: seizures (n = 4) and confusion/coma (n = 4).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
As many as 10% to 20% of patients undergoing kidney transplantation develop post-transplant diabetes mellitus, which is associated with increased mortality. Even borderline changes in glucose metabolism, so-called prediabetes, may involve a similar risk. A recent study by Porrini et  al. showed for the first time that such changes in glucose metabolism are in fact associated with future cardiovascular disease and death in kidney-transplanted patients. This commentary discusses the relevance and clinical implications of these new findings.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Kidney and urinary tract congenital anomalies are present in 9.5% of males under age 18. A donor in his 50s had head trauma and was found to have a horseshoe kidney. En bloc organ donation was performed after circulatory death with 41 minutes of warm ischemia time. The kidney donor profile index was 73%, final creatinine was 0.7 mg/dl, and kidney biopsies revealed 2% (right) and 3% (left) glomerulosclerosis with no fibrosis, arteriosclerosis, or arteriolosclerosis. Both kidneys had anteriorly positioned ureters, separated by a 2-cm isthmus (Figure  1).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
A 48-year-old kidney transplant recipient was admitted to our hospital with nausea, polyuria, diffuse paresthesia, and muscle weakness of all extremities. His past medical history was remarkable for renal transplantation with impaired graft function (baseline glomerular filtration rate approximately 20 ml/min per 1.73 m2) and parathyroidectomy due to an uncontrolled hyperparathyroidism. An electrocardiogram showed pronounced concave ST-segment elevations in leads II, III, and aVF suspicious of an acute ST elevation myocardial infarction as well as ascending elevations deriving from a deep S wave especially in leads V1 &nda...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
Conditions:   Osteoporosis, Osteopenia;   Renal Transplant Recipient Interventions:   Drug: Denosumab 60 mg/ml [Prolia];   Drug: Alendronate 70Mg Tab Sponsors:   Ain Shams University;   Nahda University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Kidney transplants between monozygotic twins can be done successfully without immunosuppression, with excellent outcomes, shows an analysis of twin transplants in the modern era.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nephrology News Source Type: news
In this study, we evaluated which cumulative dose of rATG was most appropriate for transplantation in NHPs. Cynomolgus monkeys were treated with intravenous 5 mg/kg rATG (Thymoglobulin®, Genzyme Ltd., UK) twice, on days 0 and 2 (a total of 10 mg/kg, n=2), or 4 times, on days 0, 1, 2, and 3 (a total of 20 mg/kg, n=6). In addition, we performed allo-KT in cynomolgus monkeys (n=4) with a cumulative 20 mg/kg dose of rATG with optimized dosing for induction therapy. We further compared immune cells, including naïve, central memory, and effector memory T cells, in reconstituted distributions in human KT patients (n=22)....
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
AbstractPurpose of ReviewThe review provides an overview of deceased donor kidney allocation in Canada.Recent FindingsOrgan donation and transplant services are organized provincially in Canada. In the absence of a national system, provincial organ allocation policies aspire to balance considerations of utility and justice consistent with national best practice recommendations established in inter-provincial initiatives. As deceased donor kidneys are not routinely shared between regions, variations in provincial allocation policy are justifiable based on regional differences in donor supply and waiting times.SummaryThe lac...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
Abstract Based on multiple studies in animal models, mesenchymal stem cell (MSC)-based therapy appears to be an innovative intervention approach with tremendous potential for the management of kidney disease. However, the clinical therapeutic effects of MSCs in either acute kidney injury (AKI) or chronic kidney disease (CKD) are still under debate. Hurdles originate from the harsh microenvironment in vivo that decreases the cell survival rate, paracrine activity and migratory capacity of MSCs after transplantation, which are believed to be the main reasons for their limited effects in clinical applications. Melato...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
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