K-Ras-ERK1/2 accelerates lung cancer cell development via mediating H3K18ac through the MDM2-GCN5-SIRT7 axis.

Conclusion: These observations disclosed that Ras-ERK1/2 promoted the development of lung cancer via decreasing H3K18ac through MDM2-mediated GCN5 degradation. These findings might provide a new therapeutic strategy for lung cancer. PMID: 31613681 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31613681?dopt=Abstract

Source: Pharmaceutical Biology - October 17, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research