Serum Retinol and Risk of Overall and Site-Specific Cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.

Serum Retinol and Risk of Overall and Site-Specific Cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Am J Epidemiol. 2019 Oct 15;: Authors: Hada M, Mondul AM, Weinstein SJ, Albanes D Abstract Retinol, the most biologically active form of vitamin A, may influence cancer-related biologic pathways. However, results from observational studies of serum retinol and cancer risk have been mixed. We prospectively examined serum retinol and risk of overall and site-specific cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n=29,104 men) conducted between 1985-1993, with follow-up through 2012. Serum retinol concentration was measured using reverse-phase high performance liquid chromatography. Cox proportional hazards models estimated the association between baseline serum retinol quintile (Q1-Q5) and overall and site-specific cancer risk in 10,789 cases. After multivariable adjustment, higher serum retinol was not associated with overall cancer risk (Q5 vs. Q1: HR=0.97, 95% CI=0.91,1.03, p-trend=0.43). Higher retinol concentrations were, however, associated with increased risk of prostate cancer (Q5 vs. Q1: HR=1.28, 95%CI=1.13,1.45, p-trend=<0.0001), and lower risk of both liver and lung cancers (Q5 vs. Q1: liver HR=0.62, 95%CI 0.42, 0.91 p-trend=0.004; lung HR=0.80, 95%CI 0.72, 0.88 p-trend=<0.0001). No associations with other cancers were observed. In this large prospective cohort analy...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research