Complete response to nivolumab for metastatic renal cell carcinoma on hemodialysis patient; a case report

Publication date: Available online 15 October 2019Source: Urology Case ReportsAuthor(s): Akito Ito, Mizuki Hisano, Makoto Takahashi, Naoki Komine, Takaya Abe, Wataru ObaraAbstractA 73-year-old-male patient with hypertension and grade 3B chronic kidney disease underwent radical nephrectomy in the year 2000. As the renal function gradually worsened, the patient was started on hemodialysis in 2003. Eleven years after nephrectomy, the metastases were pointed out. The patient received sunitinib as first-line therapy. Thereafter, as the metastatic lesions became larger, we initiated nivolumab therapy (3 mg/m2 every 2 weeks). After 52 weeks, the metastatic lesions continued showing complete response (CR). No adverse effects were observed during nivolumab treatment.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 31 May 2017 Source:The Kaohsiung Journal of Medical Sciences Author(s): Ömer Demir, Ozan Bozkurt, Serdar Çelik, Kaan Çömez, Güven Aslan, Uğur Mungan, İlhan Çelebi, Adil Esen Aim of this study is to compare the effects of partial nephrectomy (PN) and radical nephrectomy (RN) for stage I renal cell carcinoma (RCC) on renal functions in patients with diabetes mellitus (DM) and/or hypertension (HT). Charts of patients who underwent surgery for stage I RCC in our department were retrospectively reviewed and patients with DM and/or HT were enrolled. Preope...
Source: The Kaohsiung Journal of Medical Sciences - Category: Universities & Medical Training Source Type: research
Abstract PURPOSE: We investigated structural hypertrophy and functional hyperfiltration as compensatory adaptations after radical nephrectomy in patients with renal cell carcinoma according to the preoperative chronic kidney disease stage. MATERIALS AND METHODS: We retrospectively identified 543 patients who underwent radical nephrectomy for renal cell carcinoma between 1997 and 2012. Patients were classified according to preoperative glomerular filtration rate as no chronic kidney disease-glomerular filtration rate 90ml/min/1.73m(2) or greater (230, 42.4%), chronic kidney disease stage II-glomerular filtrati...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
Abstract ObjectiveTo determine whether patients with normal preoperative renal function, but who possess medical risk factors for CKD, experience poorer renal function post partial nephrectomy (PN) for renal cell carcinoma (RCC) compared to those without risk factors. MaterialsWe investigated the effect of age, hypertension (HTN) and diabetes (DM) on estimated glomerular filtration rate (eGFR) in 488 consecutive operations for RCC performed between 2005 and 2012 at six Australian tertiary referral centres. 156 patients underwent PN and 332 patients underwent radical nephrectomy (RN).We used chi‐square and binary logistic...
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Conclusions VHL/PBRM1 mutations confirmed 3rd subtype identified and under review but appears to be mis-classified tumors.  Shows value of molecular methods rather than new mechanistic insights. Integration with survival outcome—suggests molecular detailing can be prognostic Full integrative analysis in process Preliminary data can be found at http://tcga-data.nci.hih.gov/tcga/ FoxO Transcription Factors in mTORC1- Activated Renal Tumorigenesis:  Implications for the RCC Treatment Boyi Gan, MD Anderson Cancer Center FoxO Family Transcription Factors:  mammals possess FoxO...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
We are grateful to patient advocate Katherine Phillion for sharing her notes from our fall kidney cancer meeting.  Eigth International Kidney Cancer Symposium September 2009     Management of Small Renal Masses and Localized Renal Carcinoma Case Presentation and Background Robert G. Uzzo, M.D., FACS There are a lot of options available to manage small (
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
  Eighth International Kidney Cancer Symposium September 2009     Management of Small Renal Masses and Localized Renal Carcinoma Case Presentation and Background Robert G. Uzzo, M.D., FACS There are a lot of options available to manage small (
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
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