Structural analyses of inositol phosphate second messengers bound to signaling effector proteins.

Publication date: Available online 11 October 2019Source: Advances in Biological RegulationAuthor(s): Raymond D. BlindAbstract:The higher-order inositol phosphate second messengers inositol tetrakisphosphate (IP4), inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) are important signaling molecules that regulate DNA-damage repair, cohesin dynamics, RNA-editing, retroviral assembly, nuclear transport, phosphorylation, acetylation, crotonylation, and ubiquitination. This functional diversity has made understanding how inositol polyphosphates regulate cellular processes challenging to dissect. However, some inositol phosphates have been unexpectedly found in X-ray crystal structures, occasionally revealing structural and mechanistic details of effector protein regulation before functional consequences have been described. This review highlights a sampling of crystal structures describing the interaction between inositol phosphates and protein effectors. This list includes the RNA editing enzyme “adenosine deaminase that acts on RNA 2” (ADAR2), the Pds5B regulator of cohesin dynamics, the class 1 histone deacetylases (HDACs) HDAC1 and HDAC3, and the PH domain of Bruton’s tyrosine kinase (Btk). One of the most important enzymes responsible for higher-order inositol phosphate synthesis is inositol polyphosphate multikinase (IPMK), which plays dual roles in both inositol and phosphoinositide signaling. Structures of phosphoinositide lipid binding ...
Source: Advances in Biological Regulation - Category: Biology Source Type: research

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Abstract Retrospective analysis has already shown correlation between severe Chronic Periodontitis (CP) cases with human papiloma virus (HPV). Hence, we aimed to explore deep-seated infected granulation tissue removed during periodontal flap surgery procedures for residential bacterial species between HPV+ and HVP- CP cases, which may serve as good predisposition marker for oral cancer. All CP-granulation samples showed the prominence of Firmicutes, Proteobacteria, and Bacteroidetes phyla with an abundance of gram negative anaerobes, except Streptococcus. In Beta diversity nonmetric multidimensional scaling plot, ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Authors: Zhang Y, Li L, Xu Y, Zhao X, Li F Abstract The regeneration of the skin is vital to our wound healing and skin repair abilities. Adult epidermal stem cells (ESCs) have been shown to have the potential to renew old and dead skin cells, and ESCs have been implemented in stem cell-based therapies. GPR30 is a G protein-coupled membrane receptor for oestrogen, which has been shown to regulate cell proliferation and programmed cell death. Here, we examined the biological function of GPR30 in isolated adult murine ESCs. We show that GPR30 is fairly expressed in ESCs and is repressed upon ultraviolet B (UV-B) trea...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Materials Research and TechnologyAuthor(s): Inamara Amanda Souza Santos, Vanessa Rodrigues de Medeiros Santos, Willian dos Reis Lima, Aline Lima da Silva, Breno Totti Maia, José Roberto de OliveiraAbstractThe successful application of the repair and prevention of LD converters refractories technique called Slag Splashing requires a close control of the slag physicochemical properties (basicity, viscosity and surface tension), as well as suitable selection of operational parameters and geometric configurations. In this paper, a Slag Splashing proce...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
ConclusionWe demonstrated newly developed MSI-NGS with MSIcall accurately determines the MSI status of FFPE tumor tissues thorough sequencing of tumor samples alone without patient-matched normal controls. This approach could be applied to all types of solid tumors to determine responders to immune-oncology therapy.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
AbstractImmunotherapy has been recently approved for gastric (GC) and gastroesophageal-junction adenocarcinomas (GEC), and PD-L1 immunohistochemical evaluation represents a promising predictive biomarker in this oncological setting. A series of 125 gastroesophageal dysplastic lesions (52 low-grade, 73 high-grade) was investigated for PD-L1 and DNA mismatch repair proteins status. PD-L1 was positive (combined positive score (CPS)  ≥ 1) in 48 (31.0%) dysplastic lesions. A higher prevalence of PD-L1–positive cases was observed among esophageal specimens compared with gastric ones (p = 0.00...
Source: Virchows Archiv - Category: Pathology Source Type: research
In this study, Brassia campestris L. was used as the experimental material and polluted soil with cadmium was used as the experimental soil sample, to explore the competition inhibition of calcium polypeptide application on the absorption of Cd2+ by Brassia campestris L. in the growth process, as well as the effect of calcium application on the growth. Results showed that the application of calcium polypeptides significantly promoted the growth of Brassia campestris L. Calcium polypeptides could be used as high-quality fertilizer, alleviating the effect of Cd2+ stress on the growth of Brassia campestris L., and promoting t...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: Available online 8 November 2019Source: Food Research InternationalAuthor(s): Tao Wu, Yufang Gao, Junyu Hao, Jieting Geng, Jiaojiao Zhang, Jinjin Yin, Rui Liu, Wenjie Sui, Lingxiao Gong, Min ZhangAbstractThe present study investigated the anti-obesity effects and its mechanism of capsanthin (CAP) in high-fat diet-induced obese C57BL/6J mice. Compared with untreated mice on a high-fat diet for 12 weeks, CAP at 200 mg kg-1 reduced the body weight by 27.5%, significantly reversed glucose tolerance, effectively decreased the serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and trim...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 13 November 2019Source: Life SciencesAuthor(s): Maria J. Torres, Kelsey L. McLaughlin, Randall H. Renegar, Smrithi Valsaraj, K’Shylah S. Whitehurst, Omar M. Sharaf, Uma M. Sharma, Julie L. Horton, Brinda Sarathy, Justin C. Parks, Jeffrey J. Brault, Kelsey H. Fisher-Wellman, P. Darrell Neufer, Jitka A.I. ViragAbstractAimsIntracardiac injection of recombinant EphrinA1-Fc immediately following coronary artery ligation in mice reduces infarct size in both reperfused and non-reperfused myocardium, but the cellular alterations behind this phenomenon remain unknown.Main methodsHerein, 10 w...
Source: Life Sciences - Category: Biology Source Type: research
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Source: Chemical Engineering Research and Design - Category: Chemistry Source Type: research
Mortality is higher in frail patients than previously thought, researchers at Vanderbilt University Medical Center said, and therefore no procedure should be deemed 'low-risk'.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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