Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology
Publication date: Available online 28 November 2020Source: Advances in Biological RegulationAuthor(s): Isabella Rusciano, Maria Vittoria Marvi, Eric Owusu Obeng, Sara Mongiorgi, Giulia Ramazzotti, Matilde Y. Follo, Matteo Zoli, Luca Morandi, Sofia Asioli, Viscardo Paolo Fabbri, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Lucio Cocco, Stefano Ratti (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - November 30, 2020 Category: Biology Source Type: research

Phosphatidic acid: Mono- and poly-unsaturated forms regulate distinct stages of neuroendocrine exocytosis
Publication date: Available online 28 November 2020Source: Advances in Biological RegulationAuthor(s): Emeline Tanguy, Alexander Wolf, Maité Montero-Hadjadje, Stéphane Gasman, Marie-France Bader, Nicolas Vitale (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - November 30, 2020 Category: Biology Source Type: research

Editorial
Publication date: Available online 26 November 2020Source: Advances in Biological RegulationAuthor(s): Alan P. Fields (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - November 27, 2020 Category: Biology Source Type: research

The complexities of PKCα signaling in cancer
Publication date: Available online 23 November 2020Source: Advances in Biological RegulationAuthor(s): Adrian R. Black, Jennifer D. Black (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - November 23, 2020 Category: Biology Source Type: research

Editorial Board
Publication date: December 2020Source: Advances in Biological Regulation, Volume 78Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - November 8, 2020 Category: Biology Source Type: research

The phosphoinositide 5-phosphatase INPP5K: From gene structure to in vivo functions
Publication date: Available online 10 October 2020Source: Advances in Biological RegulationAuthor(s): Stéphane Schurmans, Charles-Andrew Vande Catsyne, Christophe Desmet, Bastien Moës (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - October 11, 2020 Category: Biology Source Type: research

A cancer-associated, genome protective programme engaging PKCε
Publication date: Available online 7 October 2020Source: Advances in Biological RegulationAuthor(s): Peter J. Parker, Nicola Lockwood, Khalil Davis, Joanna R. Kelly, Tanya N. Soliman, Ainara Lopez Pardo, Jacqueline J.T. Marshall, Joanna M. Redmond, Marco Vitale, Silvia Martini (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - October 9, 2020 Category: Biology Source Type: research

Therapeutic resistance in breast cancer cells can result from deregulated EGFR signaling
Publication date: Available online 28 September 2020Source: Advances in Biological RegulationAuthor(s): Linda S. Steelman, William H. Chappell, Shaw M. Akula, Stephen L. Abrams, Lucio Cocco, Lucia Manzoli, Stefano Ratti, Alberto M. Martelli, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, James A. McCubrey (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 30, 2020 Category: Biology Source Type: research

Functional proteomic analysis reveals roles for PKCδ in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy
Publication date: Available online 28 September 2020Source: Advances in Biological RegulationAuthor(s): Jordan T. Speidel, Trisiani Affandi, David N.M. Jones, Sarah E. Ferrara, Mary E. Reyland (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 30, 2020 Category: Biology Source Type: research

Recurrent copy number gains drive PKCι expression and PKCι-dependent oncogenic signaling in human cancers
Publication date: December 2020Source: Advances in Biological Regulation, Volume 78Author(s): Yi Liu, Verline Justilien, Alan P. Fields, Nicole R. Murray (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 30, 2020 Category: Biology Source Type: research

The PKC universe keeps expanding: From cancer initiation to metastasis
Publication date: Available online 24 September 2020Source: Advances in Biological RegulationAuthor(s): Nilufar Rahimova, Mariana Cooke, Suli Zhang, Martin J. Baker, Marcelo G. Kazanietz (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 25, 2020 Category: Biology Source Type: research

Investigations of mouse models during tumorigenesis revealed essential but distinct in vivo functions among the PKC family
Publication date: Available online 19 September 2020Source: Advances in Biological RegulationAuthor(s): Michael Leitges (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 21, 2020 Category: Biology Source Type: research

Recurrent copy number gains drive protein kinase Cι expression and oncogenic signaling in human cancers
Publication date: Available online 12 September 2020Source: Advances in Biological RegulationAuthor(s): Yi Liu, Verline Justilien, Alan P. Fields, Nicole R. Murray (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 13, 2020 Category: Biology Source Type: research

The roles of osteocalcin in lipid metabolism in adipose tissue and liver
Publication date: Available online 10 September 2020Source: Advances in Biological RegulationAuthor(s): Takahito Otani, Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Hiroshi Takeuchi, Tetsuichiro Inai, Masato Hirata (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 12, 2020 Category: Biology Source Type: research

Cross-correlations between motifs in the 5′-UTR of DAT1 gene: Findings from Parkinson’s disease
Publication date: Available online 11 September 2020Source: Advances in Biological RegulationAuthor(s): Xhensina Tafani, Esterina Pascale, Francesco Fattapposta, Mariangela Pucci, Claudio D'addario, Walter Adriani (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 12, 2020 Category: Biology Source Type: research

Editorial Board
Publication date: August 2020Source: Advances in Biological Regulation, Volume 77Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - August 13, 2020 Category: Biology Source Type: research

Where are we with understanding of COVID-19?
Publication date: August 2020Source: Advances in Biological Regulation, Volume 77Author(s): Shaw M. Akula, James A. McCubrey (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 22, 2020 Category: Biology Source Type: research

The clinical impact of COVID-19 epidemic in the hematologic setting
Publication date: Available online 16 July 2020Source: Advances in Biological RegulationAuthor(s): Carlo Finelli, Sarah Parisi (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 16, 2020 Category: Biology Source Type: research

Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease
Publication date: Available online 14 July 2020Source: Advances in Biological RegulationAuthor(s): Marta G. Lete, Ashutosh Tripathi, Vijay Chandran, Vytas A. Bankaitis, Mark I. McDermott (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 15, 2020 Category: Biology Source Type: research

Foreword for the Special Issue Advances in COVID-19: Biology and Clinic
Publication date: Available online 9 July 2020Source: Advances in Biological RegulationAuthor(s): James A. McCubrey, Shaw M. Akula, Bernard Payrastre (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 10, 2020 Category: Biology Source Type: research

Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression
Publication date: Available online 4 July 2020Source: Advances in Biological RegulationAuthor(s): Günther Schönrich, Martin J. Raftery, Yvonne Samstag (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - July 5, 2020 Category: Biology Source Type: research

Cancer therapy and treatments during COVID-19 era
Publication date: Available online 26 June 2020Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Saverio Candido, Massimo Libra, Kvin Lerpiriyapong, Lucio Cocco, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, William L. Blalock, Manuela Piazzi, Giuseppe Montalto, Melchiorre Cervello, Monica Notarbartolo, Jorg Basecke, James A. McCubrey (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - June 28, 2020 Category: Biology Source Type: research

Where are we with understanding of COVID-19?
Publication date: Available online 20 June 2020Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, James A. McCubrey (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - June 21, 2020 Category: Biology Source Type: research

Thromboembolic events and Covid-19
Publication date: Available online 17 June 2020Source: Advances in Biological RegulationAuthor(s): Agnès Ribes, Fanny Vardon-Bounes, Vincent Mémier, Michael Poette, Jonathan Au-Duong, Cédric Garcia, Vincent Minville, Pierre Sié, Alessandra Bura-Rivière, Sophie Voisin, Bernard Payrastre (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - June 18, 2020 Category: Biology Source Type: research

SARS-CoV-2 pandemic: An overview
Publication date: Available online 17 June 2020Source: Advances in Biological RegulationAuthor(s): Cecilia Acuti Martellucci, Maria Elena Flacco, Rosaria Cappadona, Francesca Bravi, Lorenzo Mantovani, Lamberto Manzoli (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - June 18, 2020 Category: Biology Source Type: research

NK cells: A double edge sword against SARS-CoV-2
Publication date: Available online 13 June 2020Source: Advances in Biological RegulationAuthor(s): Elena Masselli, Mauro Vaccarezza, Cecilia Carubbi, Giulia Pozzi, Valentina Presta, Prisco Mirandola, Marco Vitale (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - June 13, 2020 Category: Biology Source Type: research

Editorial Board
Publication date: May 2020Source: Advances in Biological Regulation, Volume 76Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - May 12, 2020 Category: Biology Source Type: research

Cancer genomics of lung cancer including malignant mesothelioma: A brief overview of current status and future prospects
Publication date: Available online 5 May 2020Source: Advances in Biological RegulationAuthor(s): Suresh C. Jhanwar, Xiaoliang Leon Xu, Abul H. Elahi, David H. Abramson (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - May 6, 2020 Category: Biology Source Type: research

Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells
Publication date: Available online 23 April 2020Source: Advances in Biological RegulationAuthor(s): Alessandro Poli, Roberta Fiume, Sara Mongiorgi, Antonio Zaurito, Bhavwanti Sheth, Magdalena Castellano Vidalle, Shidqiyyah Abdul Hamid, ScottT. Kimber, Francesca Campagnoli, Stefano Ratti, Isabella Rusciano, Irene Faenza, Lucia Manzoli, Nullin Divecha (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - April 24, 2020 Category: Biology Source Type: research

Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A2 inhibitors
Publication date: Available online 10 March 2020Source: Advances in Biological RegulationAuthor(s): Varnavas D. Mouchlis, Carol Mu, Renee Hammons, Edward A. Dennis (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - March 11, 2020 Category: Biology Source Type: research

Editorial Board
Publication date: January 2020Source: Advances in Biological Regulation, Volume 75Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - March 1, 2020 Category: Biology Source Type: research

Acknowledgements
Publication date: January 2020Source: Advances in Biological Regulation, Volume 75Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - March 1, 2020 Category: Biology Source Type: research

List of Participants
Publication date: January 2020Source: Advances in Biological Regulation, Volume 75Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - March 1, 2020 Category: Biology Source Type: research

Key to photograph of participants
Publication date: Available online 31 January 2020Source: Advances in Biological RegulationAuthor(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 31, 2020 Category: Biology Source Type: research

Flimsy overlay for photograph of participants
Publication date: Available online 27 January 2020Source: Advances in Biological RegulationAuthor(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 29, 2020 Category: Biology Source Type: research

Photograph of Special Lecturer Philip Cohen
Publication date: Available online 28 January 2020Source: Advances in Biological RegulationAuthor(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 29, 2020 Category: Biology Source Type: research

Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice
Publication date: Available online 26 January 2020Source: Advances in Biological RegulationAuthor(s): Andrew T. Hale, Rachel E. Brown, Zigmund Luka, Benjamin H. Hudson, Pranathi Matta, Christopher S. Williams, John D. YorkAbstract:Sulfur assimilation is an essential metabolic pathway that regulates sulfation, amino acid metabolism, nucleotide hydrolysis, and organismal homeostasis. We recently reported that mice lacking bisphosphate 3’-nucleotidase (BPNT1), a key regulator of sulfur assimilation, develop iron-deficiency anemia (IDA) and anasarca. Here we demonstrate two approaches that successfully reduce metabolic t...
Source: Advances in Biological Regulation - January 27, 2020 Category: Biology Source Type: research

Phosphoinositides in cell proliferation and metabolism
Publication date: Available online 20 January 2020Source: Advances in Biological RegulationAuthor(s): Emilio Hirsch, Federico Gulluni, Miriam MartiniAbstractPhosphoinositides (PI) are key players in many trafficking and signaling pathways. Recent advances regarding the synthesis, location and functions of these lipids have improved our understanding of how and when these lipids are generated and what their roles are in physiology and disease. In particular, PI play a central role in the regulation of cell proliferation and metabolism. Here, we will review recent advances in our understanding of PI function, regulation, and...
Source: Advances in Biological Regulation - January 20, 2020 Category: Biology Source Type: research

Editorial
Publication date: Available online 10 December 2019Source: Advances in Biological RegulationAuthor(s): Lucio Cocco (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - December 11, 2019 Category: Biology Source Type: research

Roles of DGKs in neurons: postsynaptic functions?
Publication date: Available online 28 November 2019Source: Advances in Biological RegulationAuthor(s): Casey N. Barber, Daniel M. RabenAbstractDiacylglycerol kinases (DGKs) contribute to an important part of intracellular signaling because they generate phosphatidic acid (PtdOH). Recent research has led to the discovery of ten DGK isoforms, all of which are found in the mammalian brain. Many of these isoforms have studied functions within the brain, while others lack such understanding in regards to neuronal roles, regulation, and structural dynamics. However, while previously a neuronal function for DGKθ was unknown...
Source: Advances in Biological Regulation - November 28, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: December 2019Source: Advances in Biological Regulation, Volume 74Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - November 19, 2019 Category: Biology Source Type: research

A two-way switch for inositol pyrophosphate signaling: evolutionary history and biological significance of a unique, bifunctional kinase/phosphatase.
Publication date: Available online 14 November 2019Source: Advances in Biological RegulationAuthor(s): Thomas A. Randall, Chunfang Gu, Xingyao Li, Huanchen Wang, Stephen B. ShearsAbstractThe inositol pyrophosphates (PP-InsPs) are a unique subgroup of intracellular signals with diverse functions, many of which can be viewed as reflecting an overarching role in metabolic homeostasis. Thus, considerable attention is paid to the enzymes that synthesize and metabolize the PP-InsPs. One of these enzyme families - the diphosphoinositol pentakisphosphate kinases (PPIP5Ks) - provides an extremely rare example of separate kinase and...
Source: Advances in Biological Regulation - November 15, 2019 Category: Biology Source Type: research

Recent advances in MDS mutation landscape: splicing and signalling
Publication date: Available online 5 November 2019Source: Advances in Biological RegulationAuthor(s): Matilde Y. Follo, Andrea Pellagatti, Stefano Ratti, Giulia Ramazzotti, Irene Faenza, Roberta Fiume, Sara Mongiorgi, Pann-Ghill Suh, James A. McCubrey, Lucia Manzoli, Jacqueline Boultwood, Lucio CoccoAbstractRecurrent cytogenetic aberrations, genetic mutations and variable gene expression have been consistently recognized in solid cancers and in leukaemia, including in Myelodysplastic Syndromes (MDS). Besides conventional cytogenetics, the growing accessibility of new techniques has led to a deeper analysis of the molecular...
Source: Advances in Biological Regulation - November 6, 2019 Category: Biology Source Type: research

Biological regulation of Diacylglycerol Kinases in Normal and Neoplastic Tissues: new opportunities for cancer immunotherapy.
Publication date: Available online 30 October 2019Source: Advances in Biological RegulationAuthor(s): Javier Arranz-Nicolás, Isabel MéridaAbstractIn the recent years, the arsenal of anti-cancer therapies has evolved to target T lymphocytes and restore their capacity to destroy tumor cells. However, the clinical success is limited, with a large number of patients that never responds and others that ultimately develop resistances. Overcoming the hypofunctional state imposed by solid tumors to T cells has revealed critical but challenging due to the complex strategies that tumors employ to evade the immune syste...
Source: Advances in Biological Regulation - October 31, 2019 Category: Biology Source Type: research

Structural analyses of inositol phosphate second messengers bound to signaling effector proteins
Publication date: Available online 11 October 2019Source: Advances in Biological RegulationAuthor(s): Raymond D. BlindAbstractThe higher-order inositol phosphate second messengers inositol tetrakisphosphate (IP4), inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) are important signaling molecules that regulate DNA-damage repair, cohesin dynamics, RNA-editing, retroviral assembly, nuclear transport, phosphorylation, acetylation, crotonylation, and ubiquitination. This functional diversity has made understanding how inositol polyphosphates regulate cellular processes challenging to dissect. However, some i...
Source: Advances in Biological Regulation - October 22, 2019 Category: Biology Source Type: research

Abilities of β-Estradiol to Interact with Chemotherapeutic Drugs, Signal Transduction Inhibitors and Nutraceuticals and Alter the Proliferation of Pancreatic Cancer Cells.
Publication date: Available online 18 October 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Lucio Cocco, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Marco Falasca, Giuseppe Montalto, Melchiorre Cervello, Monica Notarbartolo, Agnieszka Gizak, Dariusz RakusAbstractImproving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhan...
Source: Advances in Biological Regulation - October 19, 2019 Category: Biology Source Type: research

Three dimensional in vitro models of cancer: bioprinting multilineage glioblastoma models
In this study, we used a multi-nozzle extrusion bioprinter to establish models of glioblastoma made up of cancer and stromal cells printed within matrices comprised of alginate modified with RGDS cell adhesion peptides, hyaluronic acid and collagen-1. Methods were developed using U87MG glioblastoma cells and MM6 monocyte/macrophages, whilst more disease relevant constructs contained glioblastoma stem cells (GSCs), co-printed with glioma associated stromal cells (GASCs) and microglia. Printing parameters were optimised to promote cell-cell interaction, avoiding the ‘caging in’ of cells due to overly dense cross-...
Source: Advances in Biological Regulation - October 19, 2019 Category: Biology Source Type: research

Induction of membrane curvature by proteins involved in Golgi trafficking
Publication date: Available online 16 October 2019Source: Advances in Biological RegulationAuthor(s): Stefanie L. Makowski, Ramya S. Kuna, Seth J. FieldAbstractThe Golgi apparatus serves a key role in processing and sorting lipids and proteins for delivery to their final cellular destinations. Vesicle exit from the Golgi initiates with directional deformation of the lipid bilayer to produce a bulge. Several mechanisms have been described by which lipids and proteins can induce directional membrane curvature to promote vesicle budding. Here we review some of the mechanisms implicated in inducing membrane curvature at the Go...
Source: Advances in Biological Regulation - October 17, 2019 Category: Biology Source Type: research

Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain
Publication date: Available online 15 October 2019Source: Advances in Biological RegulationAuthor(s): Sandeep K. Singh, Sarah SpiegelAbstractTriple-negative breast cancer (TNBC) is very aggressive with high metastatic and mortality rates and unfortunately, except for chemotherapy, there are few therapeutic options. The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) regulates numerous processes important for cancer progression, metastasis, and neuropathic pain. The pro-drug FTY720 (fingolimod, Gilenya) used to treat multiple sclerosis is phosphorylated in the body to a S1P mimic that binds to S1PRs, except ...
Source: Advances in Biological Regulation - October 16, 2019 Category: Biology Source Type: research

Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics
Publication date: Available online 15 October 2019Source: Advances in Biological RegulationAuthor(s): João T. Barata (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - October 16, 2019 Category: Biology Source Type: research