Structural analyses of inositol phosphate second messengers bound to signaling effector proteins
Publication date: Available online 11 October 2019Source: Advances in Biological RegulationAuthor(s): Raymond D. BlindAbstractThe higher-order inositol phosphate second messengers inositol tetrakisphosphate (IP4), inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) are important signaling molecules that regulate DNA-damage repair, cohesin dynamics, RNA-editing, retroviral assembly, nuclear transport, phosphorylation, acetylation, crotonylation, and ubiquitination. This functional diversity has made understanding how inositol polyphosphates regulate cellular processes challenging to dissect. However, some i...
Source: Advances in Biological Regulation - October 22, 2019 Category: Biology Source Type: research

Abilities of β-Estradiol to Interact with Chemotherapeutic Drugs, Signal Transduction Inhibitors and Nutraceuticals and Alter the Proliferation of Pancreatic Cancer Cells.
Publication date: Available online 18 October 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Lucio Cocco, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Marco Falasca, Giuseppe Montalto, Melchiorre Cervello, Monica Notarbartolo, Agnieszka Gizak, Dariusz RakusAbstractImproving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhan...
Source: Advances in Biological Regulation - October 19, 2019 Category: Biology Source Type: research

Three dimensional in vitro models of cancer: bioprinting multilineage glioblastoma models
In this study, we used a multi-nozzle extrusion bioprinter to establish models of glioblastoma made up of cancer and stromal cells printed within matrices comprised of alginate modified with RGDS cell adhesion peptides, hyaluronic acid and collagen-1. Methods were developed using U87MG glioblastoma cells and MM6 monocyte/macrophages, whilst more disease relevant constructs contained glioblastoma stem cells (GSCs), co-printed with glioma associated stromal cells (GASCs) and microglia. Printing parameters were optimised to promote cell-cell interaction, avoiding the ‘caging in’ of cells due to overly dense cross-...
Source: Advances in Biological Regulation - October 19, 2019 Category: Biology Source Type: research

Induction of membrane curvature by proteins involved in Golgi trafficking
Publication date: Available online 16 October 2019Source: Advances in Biological RegulationAuthor(s): Stefanie L. Makowski, Ramya S. Kuna, Seth J. FieldAbstractThe Golgi apparatus serves a key role in processing and sorting lipids and proteins for delivery to their final cellular destinations. Vesicle exit from the Golgi initiates with directional deformation of the lipid bilayer to produce a bulge. Several mechanisms have been described by which lipids and proteins can induce directional membrane curvature to promote vesicle budding. Here we review some of the mechanisms implicated in inducing membrane curvature at the Go...
Source: Advances in Biological Regulation - October 17, 2019 Category: Biology Source Type: research

Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain
Publication date: Available online 15 October 2019Source: Advances in Biological RegulationAuthor(s): Sandeep K. Singh, Sarah SpiegelAbstractTriple-negative breast cancer (TNBC) is very aggressive with high metastatic and mortality rates and unfortunately, except for chemotherapy, there are few therapeutic options. The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) regulates numerous processes important for cancer progression, metastasis, and neuropathic pain. The pro-drug FTY720 (fingolimod, Gilenya) used to treat multiple sclerosis is phosphorylated in the body to a S1P mimic that binds to S1PRs, except ...
Source: Advances in Biological Regulation - October 16, 2019 Category: Biology Source Type: research

Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics
Publication date: Available online 15 October 2019Source: Advances in Biological RegulationAuthor(s): João T. Barata (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - October 16, 2019 Category: Biology Source Type: research

MicroRNA dysregulation and multi-targeted therapy for cancer treatment
Publication date: Available online 13 October 2019Source: Advances in Biological RegulationAuthor(s): Veronica Balatti, Carlo M. CroceAbstractWe established that loss of miR-15a/16–1 genes on chromosome 13q14 is the most common alteration in Chronic Lymphocytic Leukemia (CLL) and that miR-15/16 are crucial negative regulator of BCL-2, an antiapoptotic gene overexpressed in most CLLs and in many other malignancies. We have also shown that miR-15/16 target ROR1, a cell surface receptor for Wnt5a which can enhance growth/survival of CLL cells. Interestingly, ROR1 is expressed by many cancers, but not by normal adult tis...
Source: Advances in Biological Regulation - October 14, 2019 Category: Biology Source Type: research

Structural analyses of inositol phosphate second messengers bound to signaling effector proteins.
Publication date: Available online 11 October 2019Source: Advances in Biological RegulationAuthor(s): Raymond D. BlindAbstract:The higher-order inositol phosphate second messengers inositol tetrakisphosphate (IP4), inositol pentakisphosphate (IP5) and inositol hexakisphosphate (IP6) are important signaling molecules that regulate DNA-damage repair, cohesin dynamics, RNA-editing, retroviral assembly, nuclear transport, phosphorylation, acetylation, crotonylation, and ubiquitination. This functional diversity has made understanding how inositol polyphosphates regulate cellular processes challenging to dissect. However, some ...
Source: Advances in Biological Regulation - October 13, 2019 Category: Biology Source Type: research

A high energy phosphate jump - from pyrophospho-inositol to pyrophospho-serine
Publication date: Available online 8 October 2019Source: Advances in Biological RegulationAuthor(s): Shubhra Ganguli, Akruti Shah, Aisha Hamid, Arpita Singh, Ravichand Palakurti, Rashna BhandariAbstractInositol pyrophosphates (PP-IPs) are a class of energy rich metabolites present in all eukaryotic cells. The hydroxyl groups on these water soluble derivatives of inositol are substituted with diphosphate and monophosphate moieties. Since the discovery of PP-IPs in the early 1990s, enormous progress has been made in uncovering pleiotropic roles for these small molecules in cellular physiology. PP-IPs exert their effect on pr...
Source: Advances in Biological Regulation - October 10, 2019 Category: Biology Source Type: research

Phosphatidylinositol 3 monophosphate metabolizing enzymes in blood platelet production and in thrombosis
Publication date: Available online 7 October 2019Source: Advances in Biological RegulationAuthor(s): Marie Bellio, Manuella Caux, Alicia Vauclard, Gaëtan Chicanne, Marie-Pierre Gratacap, Anne-Dominique Terrisse, Sonia Severin, Bernard PayrastreAbstractBlood platelets, produced by the fragmentation of megakaryocytes, play a key role in hemostasis and thrombosis. Being implicated in atherothrombosis and other thromboembolic disorders, they represent a major therapeutic target for antithrombotic drug development. Several recent studies have highlighted an important role for the lipid phosphatidylinositol 3 monophosphate ...
Source: Advances in Biological Regulation - October 9, 2019 Category: Biology Source Type: research

Illuminating insights into opsin 3 function in the skin
Publication date: Available online 7 October 2019Source: Advances in Biological RegulationAuthor(s): Lauren E. Olinski, Erica M. Lin, Elena OanceaABSTRACTBecause sunlight is essential for human survival, we have developed complex mechanisms for detecting and responding to light stimuli. The eyes and skin are major organs for sensing light and express several light-sensitive opsin receptors. These opsins mediate cellular responses to spectrally-distinct wavelengths of visible and ultraviolet light. How the eyes mediate visual phototransduction is well studied, but less is known about how the skin detects light. Both human a...
Source: Advances in Biological Regulation - October 9, 2019 Category: Biology Source Type: research

Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: an update
Publication date: Available online 7 October 2019Source: Advances in Biological RegulationAuthor(s): Ana Raquel Ramos, Somadri Ghosh, Tara Suhel, Clément Chevalier, Eric Owusu Obeng, Bohumil Fafilek, Pavel Krejci, Benjamin Beck, Christophe ErneuxAbstractPhosphoinositides (PIs) are phosphorylated derivatives of phosphatidylinositol. They act as signaling molecules linked to essential cellular mechanisms in eukaryotic cells, such as cytoskeleton organization, mitosis, polarity, migration or invasion. PIs are phosphorylated and dephosphorylated by a large number of PI kinases and PI phosphatases acting at the 5-, 4- an...
Source: Advances in Biological Regulation - October 9, 2019 Category: Biology Source Type: research

Cellular signaling and epigenetic regulation of gene expression in leukemia
Publication date: Available online 5 October 2019Source: Advances in Biological RegulationAuthor(s): Chandrika Gowda, Chunhua Song, Yali Ding, Soumya Iyer, Pavan Dhanyamraju, Mary McGrath, Yevgeniya Bamme, Mario Soliman, Shriya Kane, Jonathon L. Payne, Sinisa DovatAbstractAlterations in normal regulation of gene expression is one of the key features of hematopoietic malignancies. In order to gain insight into the mechanisms that regulate gene expression in these diseases, we dissected the role of the Ikaros protein in leukemia. Ikaros is a DNA-binding, zinc finger protein that functions as a transcriptional regulator and a...
Source: Advances in Biological Regulation - October 6, 2019 Category: Biology Source Type: research

HOIL-1, an atypical E3 ligase that controls MyD88 signalling by forming ester bonds between ubiquitin and components of the Myddosome.
Publication date: Available online 5 October 2019Source: Advances in Biological RegulationAuthor(s): Philip Cohen, Ian R. Kelsall, Sambit K. Nanda, Jiazhen ZhangSummaryComponents of bacteria and viruses activate Toll-Like Receptors in host cells, triggering the formation of the Myddosome and a signalling network that culminates in the production and release of the inflammatory mediators required to combat pathogenic infection. The Myddosome initiates signalling by recruiting and activating five E3 ligases that generate hybrid ubiquitin chains and attaching them to components of the Myddosome. These ubiquitin chains act as ...
Source: Advances in Biological Regulation - October 5, 2019 Category: Biology Source Type: research

Mice lacking DGKε show increased beige adipogenesis in visceral white adipose tissue after long-term high fat diet in a COX-2- dependent manner
Publication date: Available online 5 October 2019Source: Advances in Biological RegulationAuthor(s): Tomoyuki Nakano, Matthew K. Topham, Kaoru GotoAbstractAdipose tissue is a central site for energy storage in the form of triglyceride (TG). Under excess energy conditions, TG is synthesized by acylation of diacylglycerol (DG), whereas TG is broken down into DG and free fatty acid, which provide energy for mitochondrial lipid oxidation when needed. In this regard, DG is not merely an intermediate metabolite for TG metabolism; it also serves as a signaling molecule. DG kinase (DGK) phosphorylates DG to produce phosphatidic ac...
Source: Advances in Biological Regulation - October 5, 2019 Category: Biology Source Type: research

Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease
This article highlights research deciphering the role of regulatory subunits in PI3K signaling and their involvement in human disease. (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - September 28, 2019 Category: Biology Source Type: research

Oncogenic Protein Kinase Cι Signaling Mechanisms in Lung Cancer: Implications for improved Therapeutic Strategies
Publication date: Available online 25 September 2019Source: Advances in Biological RegulationAuthor(s): Ning Yin, Yi Liu, Nicole R. Murray, Alan P. FieldsAbstractProtein Kinase Cι (PKCι) is a major oncogene involved in the initiation, maintenance and progression of numerous forms of human cancer. In the lung, PKCι is necessary for the maintenance of the transformed phenotype of the two major forms of non-small cell lung cancer (NSCLC), lung adenocarcinoma (LADC) and lung squamous cell carcinoma (LSCC). In addition, PKCι is necessary for both LADC and LSCC tumorigenesis by establishing and maintaining a ...
Source: Advances in Biological Regulation - September 26, 2019 Category: Biology Source Type: research

Splicing factor mutant myelodysplastic syndromes: recent advances
Publication date: Available online 19 September 2019Source: Advances in Biological RegulationAuthor(s): Andrea Pellagatti, Jacqueline BoultwoodAbstractThe myelodysplastic syndromes (MDS) are common myeloid malignancies showing frequent progression to acute myeloid leukemia (AML). Pre-mRNA splicing is an essential cellular process carried out by the spliceosome. Mutations in splicing factor genes (including SF3B1, SRSF2, U2AF1 and ZRSR2) occur in over half of MDS patients and result in aberrant pre-mRNA splicing of many target genes, implicating aberrant spliceosome function in MDS disease pathogenesis. Recent functional st...
Source: Advances in Biological Regulation - September 21, 2019 Category: Biology Source Type: research

The function of PLCγ1 in developing mouse mDA system
Publication date: Available online 19 September 2019Source: Advances in Biological RegulationAuthor(s): Du-Seock Kang, Il Shin Kim, Ja-Hyun Baik, Daesoo Kim, Lucio Cocco, Pann-Ghill SuhAbstractDuring neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally well-coordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the co...
Source: Advances in Biological Regulation - September 21, 2019 Category: Biology Source Type: research

Insulin-like growth factor (IGF) signaling in T-cell acute lymphoblastic leukemia
Publication date: Available online 15 September 2019Source: Advances in Biological RegulationAuthor(s): Samuel Gusscott, Francesco Tamiro, Vincenzo Giambra, Andrew P. WengAbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer, characterized by an uncontrolled expansion and accumulation of T-cell progenitors. During leukemic progression, immature T cells grow abnormally and occupy the bone marrow compartment, thereby interfering with the production of normal blood cells. Pediatric T-ALL is curable with intensive chemotherapy, but there are significant, long-term side effects and ∼20% of patients suf...
Source: Advances in Biological Regulation - September 16, 2019 Category: Biology Source Type: research

NSAID Therapy for PIK3CA-Altered Colorectal, Breast, and Head and Neck Cancer
Publication date: Available online 15 September 2019Source: Advances in Biological RegulationAuthor(s): Yi Cai, Andrew Yousef, Jennifer R. Grandis, Daniel E. JohnsonAbstractEpidemiologic evidence indicates that regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) provides a protective effect against the development of colorectal, breast, and head and neck cancers. Genomic characterization of these cancers has lent considerable insight into the subpopulations of cancer patients who are most likely to benefit from NSAID therapy. The PIK3CA gene encodes the catalytic subunit of phosphatidylinositol 3-kinase (PI3K) and...
Source: Advances in Biological Regulation - September 16, 2019 Category: Biology Source Type: research

Altered chondrocyte differentiation, matrix mineralization and MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse model of opsismodysplasia
Publication date: Available online 5 September 2019Source: Advances in Biological RegulationAuthor(s): Charles-Andrew Vande Catsyne, Sufyan Ali Sayyed, Patricia Molina-Ortiz, Bastien Moes, David Communi, Joséphine Muller, Roy Heusschen, Jo Caers, Abdelhalim Azzi, Christophe Erneux, Stéphane SchurmansAbstractOpsismodysplasia (OPS) is a rare but severe autosomal recessive skeletal chondrodysplasia caused by inactivating mutations in the Inppl1/Ship2 gene. The molecular mechanism leading from Ship2 gene inactivation to OPS is currently unknown. Here, we used our Ship2Δ/Δ mouse expressing reduced amou...
Source: Advances in Biological Regulation - September 6, 2019 Category: Biology Source Type: research

New advances in targeting aberrant signaling pathways in T-cell Acute Lymphoblastic Leukemia
Publication date: Available online 5 September 2019Source: Advances in Biological RegulationAuthor(s): Francesca Paganelli, Annalisa Lonetti, Laura Anselmi, Alberto M. Martelli, Camilla Evangelisti, Francesca ChiariniAbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disorder characterized by malignant transformation of immature progenitors primed towards T-cell development.Over the past 15 years, advances in the molecular characterization of T-ALL have uncovered oncogenic key drivers and crucial signaling pathways of this disease, opening new chances for the development of novel therapeutic strategies. C...
Source: Advances in Biological Regulation - September 6, 2019 Category: Biology Source Type: research

MicroRNAs and their involvement in T-ALL: a brief overview
Publication date: Available online 5 September 2019Source: Advances in Biological RegulationAuthor(s): Nádia C. Correia, João T. BarataAbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy in which the transformed clone is arrested during T-cell development. Several genetic and epigenetic events have been implicated in this transformation. MicroRNAs (miRNAs) are small, non-coding RNAs that primarily function as endogenous translational repressors of protein-coding genes. The involvement of miRNAs in the regulation of cancer progression is well-established, namely by down-regulating t...
Source: Advances in Biological Regulation - September 5, 2019 Category: Biology Source Type: research

Multi-omic approaches to improve outcome for T-cell acute lymphoblastic leukemia patients
Publication date: Available online 26 August 2019Source: Advances in Biological RegulationAuthor(s): Jordy C.G. van der Zwet, Valentina Cordo, Kirsten Canté-Barrett, Jules P.P. MeijerinkAbstractIn the last decade, tremendous progress in curative treatment has been made for T-ALL patients using high-intensive, risk-adapted multi-agent chemotherapy. Further treatment intensification to improve the cure rate is not feasible as it will increase the number of toxic deaths. Hence, about 20% of pediatric patients relapse and often die due to acquired therapy resistance. Personalized medicine is of utmost importance to furt...
Source: Advances in Biological Regulation - August 28, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: August 2019Source: Advances in Biological Regulation, Volume 73Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - August 17, 2019 Category: Biology Source Type: research

The role of phospholipase Cβ on the plasma membrane and in the cytosol: How modular domains enable novel functions
Publication date: Available online 29 July 2019Source: Advances in Biological RegulationAuthor(s): Suzanne ScarlataAbstractPhospholipase Cβ (PLCβ) is a signaling enzyme activated by G proteins to generate calcium signals. The catalytic core of PLCβ is surrounded by modular domains that mediate the interaction of the enzyme with known protein partners on the plasma membrane. The C-terminal region PLCβ contains a novel coiled-coil domain that is required for Gαq binding and activation. Recent work has shown that this domain also binds a number of cytosolic proteins that regulate protein translation,...
Source: Advances in Biological Regulation - August 11, 2019 Category: Biology Source Type: research

A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria
We report a molecular genetic approach that reconstitutes eukaryotic inositide lipid and soluble pathways in a prokaryotic cell which inherently lack inositide kinases and phosphatases in their genome. By expressing synthetic cassettes of eukaryotic genes, we have reconstructed the heterologous formation of a range of inositide lipids, including PI(3)P, PI(4,5)P2 and PIP3. In addition, we report the reconstruction of lipid-dependent production of inositol hexakisphosphate (IP6). Our synthetic system is scalable, reduces confounding metabolic issues, for example it is devoid of inositide phosphatases and orthologous kinases...
Source: Advances in Biological Regulation - July 31, 2019 Category: Biology Source Type: research

The Role of Phospholipase Cβ on the Plasma Membrane and Cytosol: How Modular Domains Enable Novel Functions
Publication date: Available online 29 July 2019Source: Advances in Biological RegulationAuthor(s): Suzanne ScarlataAbstractPhospholipase Cβ (PLCβ) is a signaling enzyme activated by G proteins to generate calcium signals. The catalytic core of PLCβ is surrounded by modular domains that mediate the interaction of the enzyme with known protein partners on the plasma membrane. The C-terminal region PLCβ contains a novel coiled-coil domain that is required for Gαq binding and activation. Recent work has shown that this domain also binds a number of cytosolic proteins that regulate protein translation,...
Source: Advances in Biological Regulation - July 30, 2019 Category: Biology Source Type: research

Protein-protein interaction analysis highlights the role of septins in membrane enclosed lumen and mRNA processing
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Christophe Desterke, Ama Gassama-DiagneAbstractSeptins are a family of GTP-binding proteins that assemble into non-polar filaments which can be recruited to negatively charged membranes and serve as a scaffold to recruit cytosolic proteins and cytoskeletal elements such as microtubules and actin so that they can perform their important biological functions. Human septins consist of four groups, each with 13 members, and filaments formation usually involve members from each group in specific positions. However, little is known...
Source: Advances in Biological Regulation - July 28, 2019 Category: Biology Source Type: research

ZEB2 in T-cells and T-ALL
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Stien De Coninck, Geert Berx, Tom Taghon, Pieter Van Vlierberghe, Steven GoossensAbstractThe identification of the rare but recurrent t(2;14)(q22;q32) translocation involving the ZEB2 locus in T-cell acute lymphoblastic leukemia, suggested that ZEB2 is an oncogenic driver of this high-risk subtype of leukemia. ZEB2, a zinc finger E-box homeobox binding transcription factor, is a master regulator of cellular plasticity and its expression is correlated with poor overall survival of cancer patients. Recent loss- and gain-of-func...
Source: Advances in Biological Regulation - July 27, 2019 Category: Biology Source Type: research

The TCR/CD3 complex in leukemogenesis and as a therapeutic target in T-cell acute lymphoblastic leukemia
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Nuno R. dos Santos, Jacques Ghysdael, Christine Tran QuangAbstractT-cell acute lymphoblastic leukemia (T-ALL) arises from T cell precursors and is characterized by expression of many lineage-specific proteins. While T-cell antigen receptor (TCR) signaling and its strength are central for thymocyte development, mature T cell homeostasis and immune responses, their roles in T-ALL remain undetermined. Indeed, in contrast to mouse models, in which absence of TCR or major histocompatibility complex binding does not impact on leuke...
Source: Advances in Biological Regulation - July 27, 2019 Category: Biology Source Type: research

Desperately seeking a home marrow niche for T-cell acute lymphoblastic Leukaemia
Publication date: Available online 27 July 2019Source: Advances in Biological RegulationAuthor(s): Julien Calvo, Lucine Fahy, Benjamin Uzan, Françoise PflumioAbstractT-cell acute leukemia is a hematologic malignancy that results from the progressive acquisition of genomic abnormalities in T-cell progenitors/precursors. T-ALL is commonly thought to originate from the thymus albeit recent literature describes the possible acquisition of first oncogenic hits in hematopoietic progenitor cells of the bone marrow (BM). The journey of T-ALL from its arising to full blown expansion meets different microenvironments, includi...
Source: Advances in Biological Regulation - July 27, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: May 2019Source: Advances in Biological Regulation, Volume 72Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - April 27, 2019 Category: Biology Source Type: research

ABCC3 is a novel target for the treatment of pancreatic cancer
Publication date: Available online 24 April 2019Source: Advances in Biological RegulationAuthor(s): Aleksandra Adamska, Riccardo Ferro, Rossano Lattanzio, Emily Capone, Alice Domenichini, Verena Damiani, Giovanna Chiorino, Begum Gokcen Akkaya, Kenneth J. Linton, Vincenzo De Laurenzi, Gianluca Sala, Marco FalascaAbstractPancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To a...
Source: Advances in Biological Regulation - April 25, 2019 Category: Biology Source Type: research

Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells
Publication date: Available online 21 April 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Massimo Libra, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Weifeng Mao, Heng-Liang LinAbstractPancreatic cancer is devastating cancer worldwide with few if any truly effective therapies. Pancreatic cancer has an increasing incidence and may become the sec...
Source: Advances in Biological Regulation - April 22, 2019 Category: Biology Source Type: research

Phosphoinositide spatially free AKT/PKB activation to all membrane compartments
Publication date: Available online 11 April 2019Source: Advances in Biological RegulationAuthor(s): Narendra Thapa, Hudson Tyler Horn, Richard A. AndersonAbstractSer and Thr kinase AKT also known as protein kinase B (PKB) was discovered more than two and half decades ago and is one of the key downstream molecules in the phosphoinositide 3-kinase signaling pathways. The pleiotropic effects of this kinase have attracted intense interest and limelight in cancer biology, cancer therapy, diabetes, and cardiovascular diseases. Authors may refer to other more comprehensive and recent reviews on AKT/PKB (Manning and Cantley, 2007;...
Source: Advances in Biological Regulation - April 13, 2019 Category: Biology Source Type: research

Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship
Publication date: Available online 11 April 2019Source: Advances in Biological RegulationAuthor(s): Meena Jhanwar-Uniya, John V. Wainwright, Avinash L. Mohan, Michael E. Tobias, Raj Murali, Chirag D. Gandhi, Meic H. SchmidtAbstractActivation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical PI3K/Akt/mTOR signaling cascade is commonly upregulated due to loss of the tumor suppressorm PTEN, a phosphatase that acts antagonistically to the kinase (PI3K) in conversion of PIP2 to PIP3. mTOR forms two multiprotein complexes,...
Source: Advances in Biological Regulation - April 13, 2019 Category: Biology Source Type: research

Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction
Publication date: Available online 6 April 2019Source: Advances in Biological RegulationAuthor(s): Rhîan Gaenor Jacobsen, Fatemeh Mazloumi Gavgani, Amanda J. Edson, Marianne Goris, Altanchimeg Altankhuyag, Aurélia E. LewisAbstractBiomolecular interactions between proteins and polyphosphoinositides are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the development of many diseases. Polyphosphoinositides (PPIns) are phosphorylated derivatives of phosphatidylinositol and consist of seven species with different phosphate combi...
Source: Advances in Biological Regulation - April 7, 2019 Category: Biology Source Type: research

Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals
Publication date: Available online 15 March 2019Source: Advances in Biological RegulationAuthor(s): Saverio Candido, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Matilde Y. Follo, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Paolo Lombardi, Weifeng Mao, Giuseppe Montalto, Melchiorre Cervello, Dariusz Rakus, Agnieska Gizak, Heng-Liang Lin, Massimo LibraAbstractMutations at the TP53 gene are readily detected (approximately 50–75%) in pancreatic ductal adenocarcinoma (PDAC) patients. TP53 was previously thought to be a d...
Source: Advances in Biological Regulation - March 16, 2019 Category: Biology Source Type: research

Fructose-1,6-bisphosphatase: From a glucose metabolism enzyme to multifaceted regulator of a cell fate
Publication date: Available online 9 March 2019Source: Advances in Biological RegulationAuthor(s): Agnieszka Gizak, Przemyslaw Duda, Janusz Wisniewski, Dariusz RakusAbstractFructose-1,6-bisphosphatase (FBPase) is one of the ancient, evolutionarily conserved enzymes of carbohydrate metabolism. It has been described for a first time in 1943, however, for the next half a century mostly kinetic and structural parameters of animal FBPases have been studied. Discovery of ubiquitous expression of the muscle isozyme of FBPase, thus far considered to merely regulate glycogen synthesis from carbohydrate precursors, and its nuclear l...
Source: Advances in Biological Regulation - March 9, 2019 Category: Biology Source Type: research

Pancreatic cancer tumorspheres are cancer stem-like cells with increased chemoresistance and reduced metabolic potential
Publication date: Available online 23 February 2019Source: Advances in Biological RegulationAuthor(s): Alice Domenichini, Jeanne S. Edmands, Aleksandra Adamska, Romana-Rea Begicevic, Silvano Paternoster, Marco FalascaAbstractCancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attract interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the characteristi...
Source: Advances in Biological Regulation - February 23, 2019 Category: Biology Source Type: research

Editorial Board
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research

Foreword
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research

Acknowledgments
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research

List of Participants
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research

Group Photo
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research

Key to Photograph of Participants
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research

Flimsy overlay to Group photo
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research

Carlo M. Croce Special Symp Lect ABR Vol.71
Publication date: January 2019Source: Advances in Biological Regulation, Volume 71Author(s): (Source: Advances in Biological Regulation)
Source: Advances in Biological Regulation - January 24, 2019 Category: Biology Source Type: research