Cancers, Vol. 11, Pages 1539: PARP1 Co-Regulates EP300 –BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair

In conclusion, PARP1 directs the transcription of some proliferation and DNA repair genes in breast cancer cells by the ADP-ribosylation of EP300, thereby causing its activation and marking nucleosomes for displacement by BRG1. PARP1 in rapidly dividing cells facilitates the expression of genes that confer a cancer cell phenotype. Our study shows a new mechanism that links PARP1 with the removal of DNA damage in breast cancer cells via the regulation of BRG1–EP300-dependent transcription of genes involved in DNA repair pathways.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research