Haemostatic radiotherapy for bleeding cancers of the upper gastrointestinal tract.

Haemostatic radiotherapy for bleeding cancers of the upper gastrointestinal tract.
Br J Hosp Med (Lond). 2019 Oct 02;80(10):579-583
Authors: Hughes C, Radhakrishna G
Abstract
Bleeding can cause significant morbidity in patients with upper gastrointestinal malignancies. Palliative radiotherapy can palliate bleeding effectively across numerous cancer sites such as the lung and rectum. The data available regarding the role in bleeding from upper gastrointestinal cancers are limited to a single meta-analysis, a phase 2 trial, eleven retrospective cohorts and two case reports, with the majority focusing on gastric cancer. From the data available radiotherapy appears to be a well-tolerated, effective haemostatic agent that should be considered in all patients with bleeding from an upper gastrointestinal malignancy. Questions remain regarding the radiobiology of haemostasis and the optimum fractionation schedule. There is no convincing evidence that protracted higher dose regimens provide additional benefit. Commonly used fractionation schedules use 1, 5 or 10 fractions. Short fractionation schedules have been used in patients with deteriorating performance status.
PMID: 31589516 [PubMed - in process]

Source: British Journal of Hospital Medicine - October 1, 2019 Category: Internal Medicine Authors: Hughes C, Radhakrishna G Tags: Br J Hosp Med (Lond) Source Type: research