Question 2: Does the timing of central line placement in relationship to the initiation of acute lymphoblastic leukaemia therapy change the risk of thrombosis or infection?

Question Does the timing of central line placement in relationship to the initiation of acute lymphoblastic leukaemia (ALL) therapy change the risk of thrombosis or infection? Clinical scenario You are the haematology registrar doing ward rounds with your consultant. A 3-year-old with newly diagnosed ALL is expected to start induction chemotherapy in a few days. Your consultant questions if we should consult surgery for line placement prior to induction chemotherapy or if we should wait until remission is achieved. Structured question In children with ALL (population), does placing a central line at the end of induction (intervention) rather than prior to initiating chemotherapy (comparison) decrease the likelihood of central line-related thrombosis or infection (outcome)? Search strategy A search of the literature was performed using Medical Subject Heading terms via the OVID and PubMed interface. Search terms were "Precursor cell lymphoblastic leukemia lymphoma"...
Source: Archives of Disease in Childhood - Category: Pediatrics Authors: Tags: ADC Archimedes, Oncology, Immunology (including allergy), Reproductive medicine Source Type: research